血清幽门螺杆菌抗体检测与冠心病关系初探

INITIAL PROBE OF RELATION BETWEEN HELICOBACTER PYLORI INFECTION AND CORONARY HEART DISEASE

目的：观察60例冠心病（CHD），42例高血压患者和60例正常人血清幽门螺杆菌抗体（HP-IgG）载脂蛋白B100（APOB100）和脂蛋白（a）[Lp（a）]，旨在探讨幽门螺杆菌感染在冠心病患者的感染情况以及同血脂代谢之间的关系。方法：Hp-IgGLP（a）检测采用酶联免疫分析法，APOB100采用联合火箭电泳法。结果：冠心病组中HP-IgG检出率55％，明显高于高血压组38％（P＜0．05）和正常对照组31％（P＜0．01）。其APOB100和LP（a）含量同对照组比较亦显著增高（P＜0．01）。Hp-IgG与APOB100、Lp（a）间存在有一定的相关性。结论：幽门螺杆菌感染可能是冠心病发病的独立危险因子，其机理可能是长期HP慢性感染引起APOB100、Lp（a）浓度增加，因而促发CHD发生。

Objective: To determine whether Helicobacter pylori infection is associated with the development of coronary heart disease(CHD)and whether such infection has some relation with Lipemia. Methods: Hpylori IgG (Hp-IgG),Apolipoprotein B100 (APOB100 ), and Lipoprotein(a). [LP(a)] were determined serologically in 60 consecutive patients tvith CHD and 102 controls (42 with hypertension, 60 normal persons). Results: 33/60(55%) of the cases (CHD)were Hp-IgG positive as compared with 16/42(38%. P <0. 05) and 18/60 (31%, P < 0. 01) in the control group. The concentrations of APOB100 and Lp(a) were found much higher in CHD cases than in controls. HP-IgG seropositivity may be correlated with APOB100 and LP(a). Conclusions: H pylori infection may be independently asariated with the development of CHD. The Possible mechanism was that Chronic H pylori infection might increase concentrations of APOB100and LP(a) in a way that could increase the risk of CHD.