乙醇及其代谢产物乙醛对胎鼠大脑星形胶质细胞增殖的影响

Effects of alcohol and metabolite acetaldehyde on the proliferation of astroglial cells of fetal brain

为探讨孕期饮酒致胎儿神经系统发育异常和发育迟缓机制，本研究在体外利用３Ｈ－ＴｄＲ参入胎鼠大脑星形胶质细胞以研究乙醇及其代谢产物乙醛对其增殖的影响。结果表明乙醇、乙醛均可明显抑制星形胶质细胞增殖，乙醛的抑制作用强度明显高于乙醇。结果表明，乙醇、乙醛对星形胶质细胞生长有明显抑制作用。酒精引起的神经系统发育异常很可能是乙醇及其代谢产物对星形胶质细胞增殖抑制所致。

To explore the mechanism of the retardation and abnormality of nerve system development induced by drinking alcohol during pregnancy, 3 H TdR incorporation was used to study the proliferation of astroglial cells of fetal brain induced by alcohol and its metabolite acetaldehyde in vitro.The results showed that alcohol and acetaldehyde obviously restrain the proliferation of astrocytes. The effect of restrain induced by acetaldehyde is stronger than that by alcohol. Nerve system development retardation and abnormality resulted from alcohol is likely to be the restrain of proliferation induced by alcohol and its metabolite acetaldehyde.