神经元烟碱乙酰胆碱受体受阻滞所致早老型痴呆动物模型的建立

Animal model for Alzheimer's disease based on the blockade of neuronal nicotinic acetylcholine receptors

海马区内注射Ｋ－银环蛇毒素（Ｋ－ＢＧＴ）可造成小鼠学习记忆明显障碍，以建立早老性痴呆（ＡＤ）患者学习记忆缺损模型。对小鼠的损害作用随Ｋ－ＢＧＴ剂量增加而明显增加。水迷宫多项指标测试结果表明，Ｋ－ＢＧＴ损害组小鼠与对照组小鼠相比，空间学习和记忆能力显著下降。明暗回避反应实验结果也表明，Ｋ－ＢＧＴ损害小鼠潜伏期明显缩短，错误次数增多；两种检测方法均表明Ｋ－ＢＧＴ可导致小鼠学习记忆明显障碍，而且这种损害具有持久的作用。

The intrahippocampus injection of Kappa bungarotoxin (K BGT) caused a significant impairment in learning and memory abilities of mice,in order to create an animal model for Alzheimer's disease. The spatial learning and memory abilities in the Morris water maze in the model group (K BGT impaired mice)decreased significantly compared with control group. K BGT impaired mice also showed learning and memory reduction with shorter latency and more mistakes in step through test.