α骨化醇治疗慢性肾衰继发性甲状旁腺亢进

Effects of Oral 1 a - (OH)D_3 on Secondary Hyperparathyroidism in Chronic Renal Failure Patients

目为探讨α骨化醇（1α－（OH）D3，霜叶红）治疗慢性肾衰引起继发性甲状旁腺功能亢进的疗效。方法口服1α-（OH）D3并同时服用葡萄糖酸钙三个月，观察透析组和非透析组治疗前后血Ca2+、P3-、PTH等变化。结果非透析组治疗后血Ca2+升高（P＜0．05），血P3-下降（P＜0．05）、血PTH明显下降（P＜0．001）。透析组治疗后血Ca2+升高（P＜0．05），血PTH下降（P＜0．001），血P3-虽有下降，但无统计学意义。结论α骨化醇对治疗慢性肾衰继发性甲旁亢，是一种安全有效、价格低廉的药物，与罗钙全，萌格旺有相同作用。

Objective To investigate the effects of oral 1 a-(OH)D3 on secondary hyperparathyroidism in chronic renal failure patients with dialysis or non- dialysis. Methods Oral 1 a - (OH)D3 and glucoate calcium were given for three months and then measured serum Ca2+,p3- concentration and PTH level. Results After oral 1 a - (OH) - D3 for three months, serum Ca2+ concentration was markedly increased, serum PTH level was significantly decreased than those before treatment in chronic renal failure patients with dialysis and non-dialysis. Serum P3- concentration was also decreased in chronic renal failure patients with non-dialysis. Conclusion 1 a - (OH) D3 was an effective, safe and cheap drug in correcting secondary hyperparathyroidism in chronic renal failure patients.