先天性胫骨假关节雌激素受体的免疫组织化学研究

Estrogen Receptor in Congenital Pseudoarthrosis of Tibia: An Immunohistochemical Study

目的 明确先天性胫骨假关节(CPT)不同部位病变组织雌激素受体(ER) 的含量, 探讨它与发病机制的关系。方法 采用免疫组织化学方法(SABC法) 对21 例CPT 的3 个不同取材部位所获得的63 个标本进行了ER检测。结果 CPT病变软组织的ER阳性表达率比创伤性假关节低,有极显著性差异( P< 0.01) 。结论 CPT

Objective The aim of the study is to elucidate possible pathogenesis of congenital pseudoarthrosis of tibia (CPT). Methods Sixty three specimens from three locations from 21 patients with CPT were immunostained for estrogen receptor (ER). Results The ER immuno reactivity in soft tissue of CPT was significantly lower than that in traumatic pseudoarthrosis. Conclusion ER in periosteum may be involved in the pathogenesis of CPT.