血清总胆汁酸检测对乙型病毒性肝炎肝功能判定的临床意义

CLINICAL SIGNIFICANCE OF SERUM TOTAL BILE ACIDS IN ASSES SING LIVER FUNCTION OF PATIENTS WITH HEPATITIS B

目的：探讨血清总胆汁酸对乙型肝炎患者肝功能判定的临床意义。方法：检测58例A（n＝21）、B（n＝21）、C（n＝16）不同肝功能分级（按child－pugh分）的乙肝患者及20例正常对照组的血清TBA、TBIL及ALT。结果：乙肝患者TBA水平明显高于正常对照组，且随着肝功能分级的增加（A→B→C级）而显著升高（P＜0．01）；血清TBA水平与TBIL、ALT水平呈显著正相关（r＝0．54和r＝0．59）；TBA＜71．3μmol／L可作为肝功能代偿良好的判定点。结论：血清TBA的检测对判定乙型病毒性肝炎肝实质细胞的损害及肝功能的代偿状态具有重要临床意义。

Objective: The study was designed to investigate the clinical significance of serum bile acids. Mathods:58 cases of patients with hepatitis B were divided into pops A. B and C accoaling to Child - Pugh grade, Their sserum total bile acids(TBA), total bilirubin(TBIL) and alanine aminotransferase (ALT) were examined in patients and in 20 healthy controls. Reseults: Significant increase in TBA level was found in sera of patients with hepatitis B compared with that of the coneal(P < 0. 01), and positive correlation between TBA and TBIL or ALT in sera of patients with hepatitis B were observed (r = 0. 54 and r = 0. 59aspectively). The differences among the three groups(A, B, C) were significant (P< 0.01 ). The TBA level in sera of patients with hepatitis B less than 73. 1umol/l might serve as a threshold for good compensation of liver function. Conclusion: The extensive detection of serum TBA in patients with hepatitis B is important in studying liver function and its grades.