泼尼松、环磷酰胺、阿斯匹林治疗狼疮性肾炎的临床研究

Prednisone,cyclophosphamide,aspirin therapy clinical study of lupus nephritis

目的探讨泼尼松、环磷酰胺、阿斯匹林治疗狼疮性肾炎的临床效果以及不良反应。方法将98例狼疮性肾炎患者随机分为治疗组与对照组,两组均给予泼尼松和调节血脂等基础治疗,治疗组给予环磷酰胺、阿斯匹林治疗,对照组用泼尼松和调节血脂等基础治疗;疗程均为12周。结果治疗组24h尿蛋白定量、尿素氮、血肌酐、血脂、血清清蛋白、抗核抗体、血压、临床症状等指标的改善、泼尼松的用量和复发率等明显优于对照组。结论泼尼松、环磷酰胺、阿斯匹林治疗狼疮性肾炎的效果明显好于单纯泼尼松、调节血脂等治疗的效果。

Objective To prednisone,cyclophosphamide,aspirin treatment of lupus nephritis clinical effects and adverse reactions.Methods 98 patients with lupus nephritis were randomly divided into treatment group and control group,two groups were given prednisone and regulation of blood lipids and other basic treatment group was treated with cyclophosphamide,aspirin treatment,the control group,only throwing Nepal Pine and regulation of blood lipids and other basic treatment;treatment： both 12 weeks.Results The treatment group 24h urine protein,blood urea nitrogen,serum creatinine,blood lipids,serum albumin,anti-nuclear antibodies,blood pressure,clinical symptoms and other indicators of improvement,prednisone dosage and recurrence rates significantly better than the control group.Conclusion Prednisone,cyclophosphamide,aspirin treatment of lupus nephritis significantly better than prednisone alone,regulate blood lipids and other therapeutic effects.