302株肠球菌临床分布及药物敏感性分析

Clinical Distribution and Drug Sensitivity Analysis of 302 Strains of Enterococcus

目的了解住院患者肠球菌属的临床分布及其对常用抗菌药物的耐药情况,为临床诊疗提供可靠依据。方法回顾性分析我院2005年1月~2008年12月分离出肠球菌属的住院患者的临床资料。结果临床分离肠球菌302株,其中粪肠球菌242株（80.13%）,屎肠球菌60株（19.87%）。分离出的肠球菌来自尿液标本最多（55.63%）,生殖道分泌物标本次之（25.50%）。粪肠球菌和屎肠球菌对万古霉素的敏感性最高,分别为99.17%和100.00%,对氨苄西林和青霉素的敏感性次之。结论肠球菌属已成为医院感染的重要致病菌,且细菌耐药情况日趋严重,临床治疗肠球菌属引起的感染时应根据药敏结果合理用药。

Objective To investigate the clinical distribution and antibiotic resistance of enterococcus in hospitalized patients,and to provide accurate and reliable basis for clinical diagnosis and treatment.Methods The clinical data of patients with enterococcus infection hospitalized in our hospital from January 2005 to December 2008 was retrospectively analyzed.Results 302 strains of enterococcus were isolated,among which,242（80.13%） were enterococcus faecalis,60（19.87%） were enterococcus faecium.Most enterococcus were isolated from urine specimen（55.63%）,and less from generative secretion specimen（25.50%）.The sensitivities of enterococcus faecalis and enterococcus faecium to vancomycin were the highest,which accounted for 99.17% and 100.00% respectively,and the secondary sensitivities were to ampicillin and penicillin.Conclusion Enterococci are important pathogens of nosocomial infection and its antibiotic resistance is getting worse.Reasonable use of antibiotics should be stressed in the clinical treatment of enterococcus infection according to the drug sensitivity.