细胞周期相关蛋白与哺乳动物毛细胞再生作用
摘要
细胞周期相关蛋白在哺乳动物耳蜗生长发育中发挥重要作用，不同时期这些因子的表达和失活最终形成正常的耳蜗。这些调节基因在维持细胞周期和调节毛细胞、支持细胞前体的分化中，在维持有丝分裂后的毛细胞和支持细胞的状态及存活发挥重要作用。哺乳动物毛细胞的损伤不会自发的恢复再生，会引起永久的感音神经性聋。因此，在哺乳动物中控制细胞周期相关蛋白使毛细胞再生能对耳聋患者重建听力提供另外的思路。
出处
《国际耳鼻咽喉头颈外科杂志》
2011年第3期128-130,共3页
International Journal of Otolaryngology-Head and Neck Surgery
参考文献20
-
1Albert SB,Chen ZY.Hair cell regeneration.Current Opinion in Neurobiology,2008,18(23):377-382.
-
2Chen ZY.Cell cycle,differentiation and regeneration:where to begin? Cell Cycle,2006,5(22):2609-2612.
-
3Weber T,Corbett MK,Chow LM,et al.Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells.Proc Natl Acad Sci USA,2008,105(2):781-785.
-
4Izumikawa M.Response of the flat cochlear epithelium to forced expression of Atoh1.Hear Res,2008,240(2):52-56.
-
5Pauley S,Lai E,Fritzsch B,et al.Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear.Developmental Dynamics,2006,235(9):2470-2482.
-
6Douglas A.Cotanche Genetic and pharmacological intervention for treatment/prevention of hearing loss.NIH Public Access,2008,41(5):421-443.
-
7Zine A.Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea.Mol Neurobiolo.2003,27(2):223.23-7.
-
8Zine A,Aubert A.Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear.J Neurosci,2001,21(13):4712-4720.
-
9Chen P,Segil N.p27Kip 1 links cell proliferation to morphogenesis in the developing organ of Corti.Development,1999,126(8):1581-1590.
-
10Mantela J,Jiang Z,Ylikoski J,et al.The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.Development,2005,132(10):2377-2388.
二级参考文献17
-
1张媛,胡吟燕,宋巍,郭维维,翟所强.三种基因转录因子在大鼠耳蜗大上皮嵴的表达[J].中华耳鼻咽喉头颈外科杂志,2005,40(9):664-666. 被引量：2
-
2Zine A,Aubert A,Qiu J,et al.Hesl and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear.J Neurosci,2001,21(13):4712-4720.
-
3Gale JE,Meyers JR,Perasamy A,et al.Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule.J Neruobiol,2002,50(2):81-92
-
4Zheng JL,Keller G,Gao WQ.Immunocytochemical and morphological evidence for intracellular self-repair a s an important contributor to mammalian hair cell recovery.J Neurosci,1999,19(6):2161-2170.
-
5Braid RA,Burton MD,Fashena DS,et al.Hair cell recov ery in mitotically blocked cultures of the bullfrog s accule.Proc Natl Acad Sci USA,2000,97(22):11722-11729.
-
6Berggren D,Liu W,Frenz D,et al.Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants.Hear Res,2003,180(1-2):114-125.
-
7Li H,Liu H,Heller S.Pluripotent stem cells from the adult mouse inner ear.Nat Med 2003,9(10):1293-1299.
-
8Li H,Roblin G,Liu H,et al.Generation of hair cells by stepwise differentiation of embryonic stem cells.Proc Natl Acad Sci USA,2003,100(23):13495-13500.
-
9Tateya I,Nakagawa T,Iguchi F,et al.Fate of neural stem cells grafted into injured inner ears of mice.Neuroreport,2003,14(13):1677-1681.
-
10Oesterle EC,Cunningham DE,Westrum LE,et al.Ultrastructural analysis of[3H]thymidine-labeled cells in the rat utricular macula.J Comp Neurol,2003,463(2):177-195.
-
1余红,闻心培,贾美琳,文安智,万自芬.p27^(kipl)和cyclinE蛋白及PCNA在非小细胞肺癌中表达及意义[J].贵阳医学院学报,2003,28(6):489-492. 被引量：1
-
2葛建荣,任国平,姚航平.细胞周期素D1和p27^(kip1)在肾癌中的表达及其意义[J].浙江大学学报（医学版）,2007,36(5):483-487. 被引量：3
-
3孙余才,胡国华,朱江.p27蛋白在喉癌组织中的表达及其临床意义[J].肿瘤防治杂志,2004,11(10):1038-1040. 被引量：1
-
4王梅,刘丽娜.胃癌中p27^(kip1)蛋白的表达及意义[J].中国误诊学杂志,2011,11(3):562-562. 被引量：1
-
5杨为贵,黄杰,马华玲,朱润庆.非小细胞肺癌组织中p33^(ING1)和p53蛋白的表达及临床意义[J].中国医师杂志,2006,8(7):977-978. 被引量：1
-
6马萍,尹元琴,王晓华,姜又红,孟凡东,隋承光.细胞周期调控因子p27^(kip1)和DI及SPF值在食管癌检测中的意义[J].中华肿瘤防治杂志,2006,13(18):1397-1399.
-
7郭丽双,黄军华,刘俊峰.内皮祖细胞与肿瘤及放疗的关系[J].中国医药导报,2013,10(10):35-37.
-
8孙传政,杨启政,陈福进.p21^(WAF1)在小儿肾母细胞瘤组织中的表达及临床意义[J].肿瘤防治杂志,2005,12(9):690-692. 被引量：2
-
9张桂东.胆囊癌组织CyclinD1和CDC25A基因表达及其临床病理意义[J].齐鲁医学杂志,2017,32(1):31-32. 被引量：2
-
10吴艳萍,李京彬,杨永滨.细胞周期调控因子在胃黏膜上皮癌变过程中的表达及意义[J].军医进修学院学报,2006,27(1):15-15.
