期刊文献+

糖皮质激素受体与变应性呼吸道疾病

原文传递
导出
摘要 吸入性糖皮质激素是目前治疗哮喘、变应性鼻炎和慢性鼻及鼻窦炎与鼻息肉等变应性呼吸道疾病中最常用也是最有效的药物,而糖皮质激素主要是通过糖皮质激素受体来发挥其作用。本文就糖皮质激素本身及其与变应性呼吸道疾病的关系做一综述。
出处 《国际耳鼻咽喉头颈外科杂志》 2011年第3期170-172,共3页 International Journal of Otolaryngology-Head and Neck Surgery
  • 相关文献

参考文献20

  • 1Passalacqua G,Albano M,Canoniea G W.Inhaled and nasal corticosteroids:safety aspects.Allergy,2000,55(1):16-33.
  • 2Garcai G,Adler M,Humbert M.Difficult asthma.Allergy,2003,58(2):114-121.
  • 3Pujols L,Mulllo J,Picado C.Glucocorticoid receptor in human respiratory epithelial cells.Neuroimmunomodulation,2009,16(5):290-299.
  • 4Breslin MB,Geng CD,Vedeckis WV Multiple promoters exist in the human GR gene,one of which is activated by glucocorticoids.Mol Endocrinol,2001,15(8):1381-1395.
  • 5Pujols L,Mullol J,Torrego A,et al.Glucocorticoid receptors in human airways.Allergy,2004,59(10):1042-1052.
  • 6Pujols L,Xaubet A,Ramirez J,et al.Expression of glucocorticoid receptor alpha and beta in steroid-sensitive and insensitive interstitial lung diseases.Thorax,2004,59(8):687-693.
  • 7Pratt WB,Toft DO.Steroid receptor interactions with heat shock protein and immunophilin chaperones.Endoer Rev,1997,18(3):306-360.
  • 8Jenkins BD,Pullen CB,Darimont BD.Novel glucocorticoid receptor coactivator effector mechanisms.Trends Endocr Metab,2001,12(3):122-126.
  • 9Hauk PJ,Goleva E,Strickland I,et al.Increased glucoeorticoid receptor β expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype.Am J Respir Crit Care Med,2002,27(3):361-367.
  • 10Charmandari E,Raji A,Kino T,et al.A novel point mutation in the ligand-binding domain(LBD)of the human glucocorticoid receptor(hGR)causing generalized glucocorticoid resistance:The importance of the C terminus of hGR LBD in conferring transactivational aetivity.J Clin Endocrinol Metab,2005,90(6):3696-3705.

二级参考文献10

  • 1Honda M,Orii F,Ayabe T,et al.Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis.Gastroenterology,2000,118:859-866.
  • 2Hamilos DL,Leung DY,Muro S,et al.GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone.J Allergy Clin Immunol,2001,108:59-68.
  • 3Christodoulopoulos P,Leung DY,Elliott MW,et al.Increased number of glucocorticoid receptor-beta expressing cells in the airways in fatal asthma.J Allergy Clin Immunol,2000,106:479-484.
  • 4Strickland I,Kisich K,Hauk PJ,et al.High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids.J Exp Med,2001,193:585-593.
  • 5Schmidt M,Lügering N,Lügering A,et al.Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis.J Immunol,2001,166:1344-1351.
  • 6Longui CA,Vottero A,Adamson PC,et al.Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia.Horm Metab Res,2000,32:401-406.
  • 7Jankowski R,Schrewelius C,Bonfils P,et al.Efficacy and tolerability of budesonide aqueous nasal spray treatment in patients with nasal polyps.Arch Otolaryngol Head Neck Surg,2001,127:447-452.
  • 8Schaaf MJ,Cidlowski JA.Molecular mechanisms of glucocorticoid action and resistance.J Steroid Biochem Mol Biol,2002,83:37-48.
  • 9Webster JC,Oakley RH,Jewell CM,et al.Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform:A mechanism for the generation of glucocorticoid resistance.PNAS,2001,98:6865-6870.
  • 10Leung DY,Hamid Q,Vottero A,et al.Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor β.J Exp Med,1997,186:1567-1574.

共引文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部