糖皮质激素受体与变应性呼吸道疾病
摘要
吸入性糖皮质激素是目前治疗哮喘、变应性鼻炎和慢性鼻及鼻窦炎与鼻息肉等变应性呼吸道疾病中最常用也是最有效的药物,而糖皮质激素主要是通过糖皮质激素受体来发挥其作用。本文就糖皮质激素本身及其与变应性呼吸道疾病的关系做一综述。
出处
《国际耳鼻咽喉头颈外科杂志》
2011年第3期170-172,共3页
International Journal of Otolaryngology-Head and Neck Surgery
参考文献20
-
1Passalacqua G,Albano M,Canoniea G W.Inhaled and nasal corticosteroids:safety aspects.Allergy,2000,55(1):16-33.
-
2Garcai G,Adler M,Humbert M.Difficult asthma.Allergy,2003,58(2):114-121.
-
3Pujols L,Mulllo J,Picado C.Glucocorticoid receptor in human respiratory epithelial cells.Neuroimmunomodulation,2009,16(5):290-299.
-
4Breslin MB,Geng CD,Vedeckis WV Multiple promoters exist in the human GR gene,one of which is activated by glucocorticoids.Mol Endocrinol,2001,15(8):1381-1395.
-
5Pujols L,Mullol J,Torrego A,et al.Glucocorticoid receptors in human airways.Allergy,2004,59(10):1042-1052.
-
6Pujols L,Xaubet A,Ramirez J,et al.Expression of glucocorticoid receptor alpha and beta in steroid-sensitive and insensitive interstitial lung diseases.Thorax,2004,59(8):687-693.
-
7Pratt WB,Toft DO.Steroid receptor interactions with heat shock protein and immunophilin chaperones.Endoer Rev,1997,18(3):306-360.
-
8Jenkins BD,Pullen CB,Darimont BD.Novel glucocorticoid receptor coactivator effector mechanisms.Trends Endocr Metab,2001,12(3):122-126.
-
9Hauk PJ,Goleva E,Strickland I,et al.Increased glucoeorticoid receptor β expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype.Am J Respir Crit Care Med,2002,27(3):361-367.
-
10Charmandari E,Raji A,Kino T,et al.A novel point mutation in the ligand-binding domain(LBD)of the human glucocorticoid receptor(hGR)causing generalized glucocorticoid resistance:The importance of the C terminus of hGR LBD in conferring transactivational aetivity.J Clin Endocrinol Metab,2005,90(6):3696-3705.
二级参考文献10
-
1Honda M,Orii F,Ayabe T,et al.Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis.Gastroenterology,2000,118:859-866.
-
2Hamilos DL,Leung DY,Muro S,et al.GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone.J Allergy Clin Immunol,2001,108:59-68.
-
3Christodoulopoulos P,Leung DY,Elliott MW,et al.Increased number of glucocorticoid receptor-beta expressing cells in the airways in fatal asthma.J Allergy Clin Immunol,2000,106:479-484.
-
4Strickland I,Kisich K,Hauk PJ,et al.High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids.J Exp Med,2001,193:585-593.
-
5Schmidt M,Lügering N,Lügering A,et al.Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis.J Immunol,2001,166:1344-1351.
-
6Longui CA,Vottero A,Adamson PC,et al.Low glucocorticoid receptor alpha/beta ratio in T-cell lymphoblastic leukemia.Horm Metab Res,2000,32:401-406.
-
7Jankowski R,Schrewelius C,Bonfils P,et al.Efficacy and tolerability of budesonide aqueous nasal spray treatment in patients with nasal polyps.Arch Otolaryngol Head Neck Surg,2001,127:447-452.
-
8Schaaf MJ,Cidlowski JA.Molecular mechanisms of glucocorticoid action and resistance.J Steroid Biochem Mol Biol,2002,83:37-48.
-
9Webster JC,Oakley RH,Jewell CM,et al.Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform:A mechanism for the generation of glucocorticoid resistance.PNAS,2001,98:6865-6870.
-
10Leung DY,Hamid Q,Vottero A,et al.Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor β.J Exp Med,1997,186:1567-1574.
共引文献8
-
1孙臻峰,陈霞芳,张速勤.布地奈德体外对鼻息肉成纤维细胞生长及凋亡的影响[J].第二军医大学学报,2007,28(6):672-674. 被引量:5
-
2孙臻峰,陈霞芳,张渊.丙酸氟替卡松局部治疗鼻息肉作用机制的探讨[J].中国临床药学杂志,2008,17(6):323-326.
-
3李友忠,卢永德,葛圣雷.鼻内镜术后布地奈德对术腔恢复及术腔黏膜修复过程的影响[J].现代中西医结合杂志,2008,17(34):5264-5266. 被引量:7
-
4袁洪,赵绰然.鼻-鼻窦炎鼻息肉糖皮质激素治疗抵抗机制的研究进展[J].中国耳鼻咽喉颅底外科杂志,2009,15(2):156-160. 被引量:4
-
5李春林,罗英,杨春平,杨影,罗璝.糖皮质激素受体α和β与突发性聋治疗的相关性[J].中国耳鼻咽喉头颈外科,2011,18(5):247-249. 被引量:7
-
6王振霖(综述),张秋航(审校).糖皮质激素抵抗性慢性鼻-鼻窦炎及其信号转导[J].中国耳鼻咽喉颅底外科杂志,2012,18(2):158-160. 被引量:1
-
7时纳.功能性鼻窦内窥镜术后术腔黏膜修复的研究[J].基层医学论坛,2012,16(28):3709-3710. 被引量:2
-
8吴四海,袁渊,徐婷,赵东菊,肖大江.术前药物综合治疗对鼻内镜下慢性鼻-鼻窦炎伴鼻息肉手术的影响[J].齐齐哈尔医学院学报,2016,37(2):168-170. 被引量:9
-
1杨小勇.利福平致急性肾功能衰竭1例报告[J].右江民族医学院学报,2003,25(2):248-248.
-
2赵东宝.糖皮质激素性骨质疏松预防和治疗新进展[J].内科理论与实践,2011,6(5):348-351. 被引量:5
-
3白爱林,谢蜀生,龙振洲.成年小鼠皮肤移植耐受诱导的实验研究[J].中国免疫学杂志,1994,10(5):274-277. 被引量:15
-
4茅允成,孙涛.肝包虫术后残腔胆汁漏并变应性类败血症1例[J].宁夏医学杂志,1991,13(1):48-48.
-
5金海峰,王梅.糖皮质激素所致骨质疏松的研究进展[J].延边大学医学学报,2008,31(2):151-154. 被引量:2
-
6阿依夏木古丽·那斯尔,帕提曼·木合买提.治疗哮喘时应预防骨质疏松症[J].新疆预防医学杂志(维吾尔文),2004,23(1):88-88.
-
7陈惠萍,曾彩虹.变应性肉芽肿性血管炎[J].肾脏病与透析肾移植杂志,1999,8(5):488-490. 被引量:4
-
8肖荣权,曾庆明.抢救重症变应性系统性血管炎所致空腔脏器穿孔成功1例[J].工企医刊,1995,8(4):93-94.
-
9何伟.糖皮质激素与股骨头坏死[J].中国处方药,2004,3(3):22-26. 被引量:5
-
10杨召,马信龙,马剑雄.糖皮质激素性骨质疏松症的发病机制[J].中国骨与关节外科,2009,2(4):328-331. 被引量:5