维生素A辅助治疗小儿肺炎的Meta分析

A meta-analysis on vitamin A supplements in the treatment of pneumonia in children

目的:系统评价维生素A辅助治疗小儿肺炎的疗效。方法:对应用维生素A辅助治疗小儿肺炎的随机对照试验或半随机对照试验进行Meta分析。结果:共纳入11个随机对照试验,Meta分析结果维生素A辅助治疗组总有效率明显高于对照组(OR=7.81,95%CI:1.41～43.23,P<0.001);能增加X线胸片阴转率(OR=7.34,95%CI:3.22～16.73,P<0.001);发热持续时间比较差异无统计学意义(WMD=-0.29,95%CI:-0.58～-0.00,P=0.05);能缩短咳嗽持续时间(WMD=-0.97,95%CI:-1.87～-0.06,P<0.05);能缩短肺部啰音消失时间(WMD=-0.61,95%CI:-0.88～-0.34,P<0.001);能缩短患儿住院时间(WMD=-0.87,95%CI:-1.61～-0.13,P<0.05)。结论:维生素A辅助治疗小儿肺炎具有较好的疗效。

Objective： To explore the safety and efficacy of vitamin A supplements in the treatment of pneumonia in children. Methods： The randomized, quasi-randomized control clinical trials regarding the safety and efficacy of vitamin A supplements in the treatment of pneumonia in children were quantitatively evaluated using meta-analysis. Results： 11 articles were included. Vitamin A supplements had a better efficacy compared with those who were not （OR=7.81, 95%CI： 1.41-43.23, P〈0.001）, and improved the signs of chest X-rays （0R=7.34, 95%CI： 322-16.73, P〈0.001）; reduced the duration of the cough, pulmonary tales, hospital stay （P〈0.05）; there was no statistically significant difference in duration of fever （WMD=-0.29, 95%CI： -0.58--0.00, P〉0.05）. Conclusion： Vitamin A suoplements is safe and effective in treating pneumonia in children.