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ZD6474对膀胱癌裸小鼠皮下移植瘤的影响

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摘要 目的:探讨ZD6474对膀胱癌裸鼠皮下移植瘤细胞凋亡的影响。方法:30只BALB/c裸鼠建立膀胱癌原位移植瘤动物模型,随机分为5组(每组6只):实验组A[0.5(mg/(kg.d)];实验组B(3(mg/kg.d)];实验组C[7(mg/(kg.d)];实验组D[10 mg/(kg.d)],分别给予ZD6474,于接种后第7、14、21、28、35天测量动物体重及MRI检查,测量肿瘤细胞直径。结果:7 mg/(kg.d)组在给予ZD6474第21天时,肿瘤直径为(1.20±0.08)mm,与3 mg/(kg.d)组[肿瘤直径(2.80±0.15)mm]比较,差异有统计学意义;10 mg/(kg.d)组与7 mg/(kg.d)相比,肿瘤直径为(1.20±0.09)mm,差异无统计学意义,但是有2例死亡,尸体解剖示肝坏死。结论:荷人膀胱癌原位移植瘤动物模型的实验,提示其对膀胱癌具有抗肿瘤作用。
作者 陈爱武
机构地区 辽宁省沈阳市于洪区人民医院
出处 《中国医药导报》 CAS 2011年第12期40-41,共2页 China Medical Herald
关键词 膀胱癌 裸鼠 ZD6474 肿瘤血管靶向治疗 内皮生长因子
分类号 R73-3 [医药卫生—肿瘤]
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参考文献7

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中国医药导报
2011年 第12期

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