甘草锌颗粒联合罗红霉素治疗痤疮92例疗效观察

The effect observation of Licorzinc Granules combined with Roxithromycin in treatment of 92 cases with acne

目的:探讨甘草锌颗粒联合罗红霉素治疗寻常性痤疮的临床疗效及安全性。方法:采用随机对照的临床实验。治疗组连续口服甘草锌颗粒、罗红霉素6～8周;对照组口服维生素B6片、螺内酯片、克林霉素分散片、栀子金花丸6～8周。每双周随访,记录皮损变化并观察不良反应,第8周判定疗效。结果:治疗组治愈67例,显效30例,有效率为90.65%;对照组治愈52例,显效24例,有效率为89.41%,两组差异无统计学意义(χ2值为0.244,P>0.05)。结论:罗红霉素联合甘草锌治疗寻常痤疮有较好的治疗效果,且安全性高,值得在临床上推广应用。

Objective： To explore clinical efficacy and safety of Lieorzine Granules combined with Roxithromyein in treat- ment of ache vulgaris. Methods： randomized controlled clinical trials was adopted, treatment group was treated with con- tinuous oral Lieorzinc Granules, Roxithromyein 6 to 8 weeks; control group was treated VitB6 Tablets, Spironolaetone Tablets, Clindamycin Dispersible Tablets, Gardenia Golden Flower pills 6 to 8 weeks. Biweekly follow-up, changes in lesions were recorded and adverse reactions were observed, the efficacy was determined in the 8th weeks. Results： In treatment group, 67 patients were cured, 30 cases had marked effect, effective rate was 90.65%; in control group 52 cases were cured, 24 cases had marked effect, effective rate was 89.41%, there were no significant difference between the two groups （X^2Value of 0.244, P〉0.05）. Conclusion： Roxithromycin in treatment of acne vulgaris with Lieorzine Granules has a good treatment result, and is safe, and worth of clinical application.