长疗程小剂量泮托拉唑和克拉霉素三联疗法根除幽门螺杆菌的疗效观察

Evaluation of long-term triple therapy with low-dose of pantoprazole and clarithromycin for the eradication of Helicobacter pylori

目的探讨泮托拉唑联合阿莫西林和克拉霉素对幽门螺杆菌治疗的效果及适当的剂量。方法来自我市8家医院的600例患者,患有胃溃疡或十二指肠溃疡,且幽门螺杆菌阳性。随机分为两组:观察组:泮托拉唑20mg+阿莫西林750mg+克拉霉素125mg,对照组:泮托拉唑40mg+阿莫西林750mg+克拉霉素250mg。各组药物均每日口服两次,疗程2周。结果对照组对幽门螺杆菌的根除率为81.7%,观察组对幽门螺杆菌的根除率为93.7%。结论泮托拉唑、阿莫西林、克拉霉素的三联疗法对幽门螺杆菌有很高的根除率,而半剂量的泮托拉唑和克拉霉素对幽门螺杆菌的治疗效果更好,且副作用少。

Objective To evaluate of long-term triple therapy with low-dose of pantoprazole and clarithromycin for the eradication of Helicobacter pylori.Methods Six hundreds patients with gastric ulcer or duodenal ulcer and Helicobacter pylori infection from 8 hospitals in our city were randomly divided into two groups.The control group were treated with pantoprazole 40 mg,amoxincillin 750 mg,and clarithromycin 250 mg,while the treatment group were treated with pantoprazole 20 mg,amoxincillin 750 mg,and clarithromycin 125 mg.The drugs were used orally twice per day,the course was two weeks.Results The eradication rate of Helicobacter pylori was 93.7% in treatment group,which was significantly higher than in control group（81.7%）（P=0.0081）.Conclusion Two-week triple therapy with low-dose of pantoprazole and clarithromycin had a higher rate for eradication of Helicobacter pylori.