期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

再生障碍性贫血的发病机制及其治疗研究进展 被引量：4

The Progress of Study on the Pathogenesis and Treatment of Aplastic Anemia
下载PDF
导出
摘要 再生障碍性贫血(AA)是由于物理、化学、生物或不明因素作用使骨髓造血干细胞和骨髓微环境严重受损,造成骨髓造血功能降低或衰竭,以全血细胞减少为主要表现的一组综合征。AA发病机理复杂,目前尚未完全明了,对AA病理机制的深入研究有利于提高AA的诊疗水平。本文就近年来AA发病机制及其治疗方面的进展作一综述。 Aplastic anemia（aplastic anemia,AA） is a blood disorder in which the bone marrow hematopoietic stem cells and bone marrow microenvironment were severely damaged cudsed by physical,chemical,biological,or unknown factors,resulting in reduced bone marrow function or failure,and manifesting mainly as pancytopenia.The pathogenesis is complicated and have not been still comprehensively understood.It will be benefit for the improvement of the diagnosis and treatment to elucidate the precise mechanism of AA.In this paper,recent progress in the pathogenesis and treatment of AA was reviewed.
作者 郑雨薇 魏志英 胡海莹
机构地区 浙江台州学院医学院检验系
出处 《四川解剖学杂志》 2011年第1期48-50,共3页 Sichuan Journal of Anatomy
关键词 再生障碍性贫血 发病机制 治疗 进展 Aplastic anemia（AA） Pathogenesis Treatment Progress
分类号 R556.5 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献15

  • 1Muir KR,Chilvers CE,Harriss C,et al.The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia:a case control investigation[J].Br J Haematol,2003,123(5):906-914.
  • 2Jancel T,Penzak SR.Antiviral therapy in patients with hematologic malignancies,transplantation,and aplastic anemia[J].Semin Hemato1,2009,46(3):230-247.
  • 3Chen JC.Animal Models for Acquired Bone Marrow Failure Syndromes[J].Clinical Medicine & Research,2005,3 (2),102-108.
  • 4Go RS,Lust JA,Phyliky RL.Aplastic anemia and pure red cell aplasia associated with large granular lymphocyte leukemia[J].Semin Hematol,2003,40(3):196-200.
  • 5Scopes J,Ismail M,Marks KJ,et al.Correction of stromal cell defect after bone marrow transplantation in aplastic anaemia[J].Br J Haematol,2001,115(3):642-652.
  • 6Gomez-Morales E,Martinez-Jaramillo G,Sdnchez-Valle E,et al.Deficient proliferation of myeloid,erythroid,and muhipotent progenitor cells in long-term marrow cultures from patients with aplastic anemia treated with immunosuppressive therapy[J].Am J Hematol,1998,59(2):149-155.
  • 7Young NS,Bacigalupo A,Marsh JC.Aplastic anemia,pathophysiology and treatment[J].Biol Blood Marrow Transplant.2010,16(1);119-125.
  • 8Gurion R,Gaher-Gvili A,Paul M,et al.Hematopoietic growth factors in aplastic anemia patients treated with immuonosuppressive therapy-systematic review and recta-analysis[J].Haematologica.2009,94(5):712-719.
  • 9王洪真,董广才.抗T细胞单抗治疗再生障碍性贫血27例临床观察[J].中国社区医师（医学专业）,2010,12(24):49-50. 被引量：1
  • 10Li X,Xu F,He Q,Wu L,et al.Comparison of immunological abnormalities of lymphocytes in bone marrow in myelodysplastic syndrome (MDS) and aplastic anemia (AA)[J].Intern Med,2010,49(14):1349-1355.

二级参考文献17

  • 1孙纪元,王四旺,谢艳华,施新猷.再生障碍性贫血的动物模型实验研究[J].中国实验动物学杂志,2000,10(4):210-212. 被引量：57
  • 2郑莜荧.中药新药临床研究指导原则试行[M].北京:中国医药科技出版社,2002:221-224.
  • 3Alexander Spire. Muhidisciplinary management of lung cancer [J].N Engl J Med, 2004, 350 (4): 379-392.
  • 4Edwards BK, Howe HL, Ries LA, et al. Annual report to the nation on the status of cancer, 1973 - 1999, featurin gimlications of age and aging on the U. S. cancer burden [J]. Cancer, 2002, 94 (10) : 2766 -2792.
  • 5Oliveira FJ, Ferrao H, Furtado E, et al. Total gastroectomy for gastric adenocarcinoma: analysis of 115 consecutive patients [ J]. Hepato gastroenterology 1999, 46 (27): 2044 -2047.
  • 6Hinterberger W.Further evidenee for Lympholcihe over-produetion in serere aplastic anemia[J].Blood,1988,72:266-272.
  • 7孙传兴.临床疾病诊断依据治愈好转标准[M].北京：人民军医出版社,1999.103.
  • 8张天泽 徐光炜.肿瘤学[M].天津：天津科学技术出版社,1996.1209.
  • 9第四届全国再障学术会议.再障性贫血诊断标准.中华血液杂志,1987,8(8):4-4.
  • 10第四届全国再障学术会议.再障性贫血疗效评价标准.中华血液杂志,1987,8(8):468-468.

共引文献108

同被引文献50

  • 1宋艳萍,胡凯,王浩.补肾活血通络方对慢性再生障碍性贫血患者血清可溶性Fas含量的影响[J].陕西中医,2008,29(6):686-687. 被引量：4
  • 2罗梅宏,周永明,胡明辉,陆嘉惠,孙曼萍,薛志忠,鲍计章.生血合剂干预下免疫介导再障小鼠骨髓核因子κB表达变化[J].中国实验方剂学杂志,2008,14(10):50-53. 被引量：1
  • 3邵宗鸿,袁烨.再生障碍性贫血免疫发病机制及免疫治疗[J].中国实用内科杂志：临床前沿版,2006,26(2):252-255. 被引量：83
  • 4Wlodarski M W, Gondek L P, Nearman Z P, et al. Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aolastic anemia and myelodysplastic syndrome [ J ]. Blood, 2006, 108 (8) :2632.
  • 5Young N S, Calado R T, Scheimgerg P. Current concepts in the pathophysiology and treatment of aplastic anemia[J]. Blood, 2006, 108(8) :2509.
  • 6Vial M, Merli A, Bacigalupo A. Analysis at the clonal level of T-cell phenotype and functions in severe aplastic anemia patients [ J ]. Blood, 1991 , 78 : 1268.
  • 7Melenhorst J J, van Krieken M, Dreef E, et al. T cells selectively infiltrate bone marrow areas with residual haemopoiesis of patients with acquired aplastic anaemia [J]. Br J Haematol, 1997, 99:517.
  • 8Rodolfo Velasco Lezama. A model for the induction of aplastic anemia bysubcutaneous administration of benzene in mice [ J ]. Toxicology,2001,162 ( 3 ) : 179.
  • 9Marsh JC, Ball SE,Cavenagh J, et al. Guidelines for the diagnosis and management of aplastic anaemia[J]. BrJ Haematol,2009,147:43-70.
  • 10Solomou EE, Rezvani K,Mielke S,et al. Deficient CD4 CD25 FOXP3 T regulatory cells in acquired aplastic anemia[J]. Blood,2007,110:1603-1606.

引证文献4

二级引证文献33

四川解剖学杂志
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部