抗HCV与血清HBV-M电化学发光检测结果相关性分析

Correlation analysis of anti-HCV and serum HBV-M by electrochemiluminescence

目的回顾性分析患者抗HCV与HBV-M检出情况,探讨HCV与HBV感染之间的相互关系。方法使用电化学发光法(ECL)比较分析196例抗HCV阳性患者与32026例抗HCV阴性患者血清HBV-M单项检出率和不同模式的检出率。结果抗HCV阳性组HBV-M检出率为73.47%;抗HCV阳性组HBsAb单阳性模式检出率低于抗HCV阴性组(P<0.05);而HBcAb单阳性模式、HBeAb和HBcAb双阳性模式、HBsAg和HBcAb双阳性模式检出率却高于抗HCV阴性组(P<0.05);抗HCV阳性组单项HBsAg、HBeAg以及HbsAb的检出率与抗HCV阴性组间差异无统计学意义(P>0.05),而单项HBeAb和HBcAb阳性率却高于HCV抗体阴性组(P<0.05)。结论 HCV与HBV共感染在人群中分布面较广,共感染后存在互相干扰抑制作用,主要表现为HBcAb、HBeAb的产生,及对保护性HBsAb产生过程的干扰与抑制。

Objective The situation of HBV M were detected through retrospective analysis of patients with anti-HCV to investigate the relationship between HCV and HBV co-infection. Methods Use the ECL method to replace the ELISA method,compara rive analysis of 196 cases of anti HCV positive serum and 30,026 cases of anti-HCV negative serum HBV infection and its detection rate and H]3V M individual detection rate of different modes. Results anti-HCV positive group with HBVM detection rate of 73. 47% ;anti-HCV positive group and individual H]3V surface antibody positive （2 ＋ ） mode detection rate was significantly lower than the anti-HCV antibody negative group; H]3V core antibody alone （5 ＋ ） mode, HBV e antibody, HBV core antibody positive （4 ＋5 ＋） mode and the HBV surface antigen,core antibody positive （1 ＋ 5 ＋） mode was significantly higher than the detection rate of HCV antibody negative group;anti HCV positive group and individual HBsAg, HBeAg and anti HBs detection rate of HCV antibody negative group with no significant difference,while the single anti-HBe and anti HBc positive rate was significantly higher than HCV antibody negative group. Conclusion HCV and HBV infection in the population distribution of overlapping covers more overlap there is interference inhibition after infection, mainly for the anti-HBc, anti HBe production, and the Protective anti-HBs production process and the suppression of interference.