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吸入性全身麻醉药对发育期神经元的电生理功能影响的研究进展 被引量：2

Effects of Inhalation Anesthetics on the Developing Neurons in Electrophysiological Function
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摘要 临床常用吸入性全身麻醉药异氟烷、七氟烷和地氟烷等均能增强机体对外源性氨酪酸(GABA)的电反应,通过GABAA发挥生物学效应。而在发育期神经元电生理功能具有阶段特异性:GABAA受体介导的氯离子外流引起神经元去极化;α氨基羟甲基唑丙酸受体尚无完整功能,N甲-基-D-天冬氨酸受体的激活依赖GABAA受体,在神经元突触形成方面起着重要的作用。此外,氯离子引导的除极还可以激活细胞膜上电压依赖性钙通道引起钙内流。发育期神经元电生理特点使其在生长发育过程中容易受到吸入性全身麻醉药的影响。 The inhalation anesthetics like isoflurane,sevoflurane and desflurane can enhance the action of exogenous GABA via GABAA receptors.However,the immature neurons have special features during the early period of synapse development：the activation of GABAA receptors depolarizes and excites neuronal membranes by a reverse chloride gradient;GABAA receptors channels operate in synergy with NMDA receptors channels in the immature neurons because of ＂silent＂ AMPA receptors channels.In addition,GABAAR-mediated chloride efflux can also activate voltage-dependent Ca2＋ channels（VDCCs） to evoke calcium influx.So,the immature neurons are vulnerable to inhalation anesthetics involved in these neuron features.
作者 赵以林 罗爱林
机构地区 华中科技大学同济医学院附属同济医院麻醉科
出处 《医学综述》 2011年第7期1069-1071,1078,共4页 Medical Recapitulate
基金 国家自然科学基金(30772086)
关键词 麻醉药 吸入 神经元 发育期 GABAA受体 电生理 Inhalation anesthetics Developing neurons GABAA receptors Electrophysiology
分类号 R614.1 [医药卫生—麻醉学]
  • 相关文献

参考文献31

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二级参考文献22

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共引文献5

同被引文献34

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引证文献2

二级引证文献7

医学综述
2011年 第7期

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