摘要
目的：观察老年冠心病患者血清铁、铁蛋白、转铁蛋白及血脂水平与冠状动脉狭窄程度的关系,探寻冠心病的发病原因。方法：对201例疑似冠心病的老年患者行冠脉造影及血清铁、铁蛋白、转铁蛋白、总胆固醇（TC）、甘油三酯、高密度脂蛋白-胆固醇（HDL-C）及低密度脂蛋白-胆固醇（LDL-C）的测定,采用Gensini评分系统衡量冠状动脉造影结果。按照Gensini评分结果将观察对象分为对照组和冠心病轻、中、重度组,应用方差分析比较各参数在四组中的分布情况,应用多因素回归分析研究Gensini评分与各参数的关系。结果：单因素方差分析显示,血清铁、血清铁蛋白、转铁蛋白/铁蛋白比值、TC及LDL-C在各组间分布差异具有显著性（F=3.519~9.414,P均〈0.05）;多因素逐步线性回归分析显示,血清铁蛋白与冠状动脉狭窄程度的评分独立相关（偏相关系数=0.182,P〈0.05）。结论：老年冠心病的发生与血清铁、铁蛋白、总胆固醇和低密度脂蛋白-胆固醇有一定的相关性,血清铁蛋白与冠状动脉狭窄程度呈独立正相关。
Objective： To investigate the relationship among levels of serum iron,ferritin,transferrin（TRF）,blood lipid and coronary artery stenosis in aged patients with coronary heart disease（CHD） as well as try to find the possible cause of CHD.Methods： A total of 201 aged patients suspected CHD underwent coronary angiography and levels of serum iron,ferritin,TRF,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C） were examined.Gensini score system was used to evaluate the results of coronary angiography.All patients were allocated into control group,mild,moderate and severe group of CHD according to the Gensini score.The above indexes in the four groups were analyzed and the relationship among serum iron,ferritin,TRF and Gensini score was further investigated by means of multiple factor regression analysis.Results： One-factor analysis of variance showed that distribution of serum iron,ferritin,TRF/ ferritin,TC and LDL-C among the four groups were significantly different（F=3.519~9.414,P0.05）.Multiple factor linear regression analysis showed that ferritin is independently positively correlate with the Gensini score of coronary artery stenosis（r=0.182,P0.05）.Conclusion： The levels of serum iron,ferritin,total cholesterol and low density lipoprotein cholesterol increase in elderly patients with coronary heart disease.Serum ferritin is independently positively correlate with coronary artery stenosis.
出处
《心血管康复医学杂志》
CAS
2011年第2期126-129,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
