低密度脂蛋白胆固醇、超敏C反应蛋白及单核细胞百分比与新疆维吾尔族冠心病的关系

Relation among low density lipoprotein-cholesterol,high sensitive C-reactive protein,percentage of monocytes and coronary heart disease in patients of Xinjiang Uygur nationality

目的：探讨低密度脂蛋白胆固醇（LDL-C）,超敏C反应蛋白（hs-CRP）,单核细胞百分比在维吾尔族冠心病（CHD）患者诊断中的意义及其与冠脉病变严重程度的关系。方法：101例拟诊为CHD的维吾尔族患者,按冠脉造影（CAG）结果分为：冠心病（CHD）组（51例）和正常对照组（50例）;冠心病组进一步分为：急性冠脉综合征（ACS）组（19例）,稳定型心绞痛（SAP）组（32例）;按冠脉病变分：单支血管病变组（23例）,双支病变组（15例）,多支病变组（13例）;按冠脉狭窄程度分为：轻度（50%~74%）组（21例）,中度（75%~94%）组（16例）,重度（95%~100%）组（14例）。检测各组LDL-C,hs-CRP,单核细胞百分比并进行统计学分析。结果：与正常对照组相比,CHD组LDL-C[（1.836±0.864）mmol/L∶（3.482±0.901）mmol/L],hs-CRP[（5.128±5.853）mg/L∶（7.845±6.114）mg/L],单核细胞百分比[（6.304±2.513）%∶（10.102±2.861）%]水平明显升高（P〈0.05~0.001）,且SAP组、ACS组患者上述指标水平依次升高（P〈0.05~0.001）;LDL-C、hs-CRP、单核细胞百分比水平在单支病变组[（2.641±0.889）mmol/L,（6.615±6.44）mg/L,（6.884±2.315）%]、双支病变组[（3.843±0.943）mmol/L,（9.521±6.91）mg/L,（8.012±2.558）%]及多支血管病变组[（4.169±0.961）mmol/L,（10.634±7.561）mg/L,（9.154±2.984）%]患者中依次升高（P〈0.05~0.001）;上述指标在冠脉病变程度轻度组[（2.886±0.921）mmol/L,（6.574±6.541）mg/L,（6.787±2.255）%],中度组[（3.641±0.896）mmol/L,（9.438±7.641）mg/L,（8.156±2.645）%],重度组[（4.212±0.994）mmol/L,（10.984±8.012）mg/L,（9.354±2.991）%]也依次升高（P〈0.05~0.001）。结论：维吾尔族患者外周血低密度脂蛋白胆固醇,超敏C反应蛋白,单核细胞百分比与冠心病的发生、发展有关,能反映冠状动脉病变程度和性质。

Objective： To investigate the significance of low density lipoprotein-cholesterol（LDL-C）,high sensitive C-reactive protein（hs-CRP） and percentage of monocytes for diagnosis of coronary heart disease（CHD） in Uygur nationality patients and their relation with severity of coronary artery disease.Methods： According to the results of coronary angiography（CAG）,101 Uygur nationality patients suspected as CHD were divided into CHD group（51 cases）and normal control group（50 cases）;CHD group was further divided into acute coronary syndrome（ACS） group（19 cases）and stable angina pectoris（SAP） group（32 cases）;according to coronary artery disease,the patients were divided into single-vessel coronary disease group（23 cases）,double-vessel coronary disease group（15 cases） and multi-vessel coronary disease group（13 cases）;according to stenosis extent of coronary artery,they were divided into mild（50%~74%） group（21 cases）,moderate（75%~94%） group（16 cases） and severe（95%~100%） group（14 cases）.Levels of LDL-C,hs-CRP and percentage of monocytes were measured and analyzed.Results： Compared with normal control group,levels of LDL-C [（1.836±0.864）mmol/L vs.（3.482±0.901）mmol/L],hs-CRP [（5.128±5.853）mg/L vs.（7.845±6.114）mg/L] and percentage of monocytes [（6.304±2.513）% vs.（10.102±2.861）%] significantly increased in CHD group（P0.05~0.001）,and levels of above indexes in SAP group and ACS group increased in turn（P0.05~0.001）;levels of LDL-C,hs-CRP and percentage of monocytes increased in turn in single-vessel coronary disease group [（2.641±0.889） mmol/L,（6.615±6.44）mg/L,（6.884±2.315）%],double-vessel coronary disease group [（3.843±0.943） mmol/L,（9.521±6.91）mg/L,（8.012±2.558）%] and multi-vessel coronary disease group [（4.169±0.961） mmol/L,（10.634±7.561）mg/L,（9.154±2.984）%],P0.05~0.001;the above indexes increased in turn in mild coronary disease group [（2.886±0.921） mmol/L,（6.574±6.541）mg/L,（6.787±2.255）%],moderate group [（3.641±0.896） mmol/L,（9.438±7.641）mg/L,（8.156±2.645）%] and severe group [（4.212±0.994） mmol/L,（10.984±8.012）mg/L,（9.354±2.991）%],P0.05~0.001.Conclusion： Levels of LDL-C,hs-CRP and percentage of monocytes in peripheral blood are related with occurrence and development of CHD in Uygur nationality patients,and they could reflect the severity of coronary artery disease.