慢性丙型肝炎患者血清HCVRNA水平与AST/ALT比例的关系

Relationship between hepatitis C virus RNA and the ratio of AST/ALT in the patients with chronic hepatitis C

目的分析抗-HCV阳性患者血清水平HCVRNA与AST/ALT活性的关系;评价AST/ALT比值,HCVRNA水平在判断丙肝患者预后方面的价值。方法采用ELISA法检测抗-HCV,阳性标本分别用荧光PCR试剂盒测定HCVRNA;全自动生化分析仪检测AST/ALT。结果 78份抗-HCV阳性标本经PCR检测后有31份标本含有HCVRNA,HCVRNA拷贝量与AST/ALT比例呈正相关。结论动态监测AST/ALT比例和HCVRNA的水平,可用于丙型肝炎的预后估计。

Objective To investigate the relationship between serum hepatitis C virus RNA and the ratio of aspartate aminotransferase to alanine aminotransferase（AST/ALT ratio） in anti-HCV positive samples of patients,and assess the prognostic validity of the ratio of AST/ALT,HCV-RNA in patients with chronic liver disease.Methods Hepatitis C virus fluorescence PCR diagnostic kit was carried out on the anti-HCV positive samples;the ratio of serum AST/ALT was measured by biochemical instrument.Results Of 78 cases,31 were positive for HCV RNA,the copies of HCV-RNA has correlation with the ratio of AST/ALT.Conclusion The ratio of AST/ALT and the copies of HCV-RNA can be dynamic measured to estimate the prognosis of HCV.