摘要
目的研究凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)、血浆凝血酶时间(TT)及D-二聚体(D-D)对各型肝脏疾病的诊断价值。方法检测30例健康体检者和87例临床已确诊为肝病患者的PT、APTT、FIB、TT和D-D。前四项采用自动血凝仪检测,后一项采用乳胶凝集法检测。结果不同的肝病患者PT、APTT、FIB、TT和D-D与健康组对比,具有不同程度的差异。肝硬化、肝癌患者PT、APTT、TT时间延长(P<0.01),FIB含量降低(P<0.01),D-D水平较高,分别为72.2%和60.0%。急性肝炎组PT时间延长(P<0.01)、APTT时间也延长(P<0.01)、TT和FIB差异无统计学意义(P>0.05)、D-D平为18.8%,慢性肝炎组PT、APTT、TT时间延长(P<0.01),FIB含量无统计学意义(P>0.05),D-D水平为7.4%。各型肝脏疾病PT、APTT、TT的值和D-D水平呈现肝硬化组>肝癌组>慢性肝炎组>急性肝炎组,而FIB则相反。结论 PT、APTT、FIB、TT和D-D可客观地评价肝病患者的凝血功能状况,并且与肝病的严重程度相一致。这可以为临床肝脏疾病的诊断、治疗、动态观察以及判断预后提供重要依据,具有重要的临床价值。
Objective To study the diagnostic value of PT,APTT,FIB,TT and D-D on the various types of liver disease.Methods TTest the value of PT,APTT,FIB,TT and DD on 30 healthy volunteers and 87 patients who had been diagnosed to liver disease.The front four items were tested by automated coagulation analyzer and the last one was tested by latex agglutination assay.Results Compared with the healthy group,the values of PT,APTT,FIB,TT and D-D of different kinds of patients with liver disease had different degrees of difference.The values of PT,APTT,TT in cirrhosis group and liver cancer group prolonged（P0.01）,FIB decreased（P0.01）,the level of D-D was higher,72.2% and 60.0% respectively.In acute hepatitis group,PT prolonged（P0.01）;APTT also prolonged（P0.05）;TT and FIB had no significant difference;the level of D-D was 18.8%.In the chronic hepatitis group,PT,APTT,TT prolonged（P0.01）;FIB had no difference;the level of D-D was 7.4%.The value of PT,APTT,FIB,TT and the level of D-D of various types of liver disease present cirrhosis group liver cancer group chronic hepatitis group acute hepatitis group,while the FIB is opposite.Conclusion PT,APTT,FIB,TT and D-D can objectively evaluate the coagulation status of patients with liver disease,which is consistent with severity of liver disease.They can provide important evidences for the diagnosis,treatment,dynamic observation and prognosis of clinical liver disease.
出处
《海南医学》
CAS
2011年第8期117-119,共3页
Hainan Medical Journal
