丝素/半水硫酸钙/磷酸钙骨水泥复合材料初探

Preliminary study of silk fibroin/calcium sulfate hemihydrate/calcium phosphate cement composite materials

在半水硫酸钙/磷酸钙骨水泥系统中添加丝素蛋白(SF)和纳米羟基磷灰石(n-HA)以改善其性能,用X-射线衍射和FT-IR光谱研究材料的结构和组分,用扫描电子显微镜观察材料的表面形态,用排液法测定材料的孔隙率,用通用力学试验机测定样品的抗压性能。结果表明,丝素/半水硫酸钙/磷酸钙骨水泥(SF/CSH/CPC)复合材料的固相与液相发生固化反应后,生成了羟基磷灰石,并含有未完全转化的磷酸四钙和无水磷酸氢钙。与纯半水硫酸钙/磷酸钙系统相比,加入SF和n-HA的复合材料的孔隙率增加,其结构和凝固时间无明显差异;添加n-HA,压缩强度有所下降,但压缩断裂功无明显差异;添加SF,虽然压缩强度也有所下降,但压缩断裂功增加明显。

The properties of calcium sulfate hemihydrate（CSH）/calcium phosphate cement（CPC） system had improved by adding silk fibroin（SF） and nano-hydroxyapatite（n-HA）.The structure and composition of materials was studied by X-ray diffraction.The surface morphology of materials was observed by scanning electron microscope.The porosity of materials was evaluated by drainage method,and the mechanical property of materials was tested by Instron Universal Testing Machine.The results showed that after the setting reaction of the solid and liquid phase of SF/CSH/CPC composites,HA was produced and tetracalcium phosphate and dicalcium phosphate anhydrous which were not totally transferred was still contained.Compared to pure CSH/CPC system,the porosity of the composites was improved when adding SF and n-HA,and the structure and setting time of them had not significant differences.The compressive strength of the composites was decreased while work-of-compressive had not significant infection when adding n-HA.The compressive strength of the composites had decreased slightly while work-of-compressive of them obviously improved when adding SF.