参仙升脉液十二指肠给药对兔病窦模型作用的实验观察

Experimental Observation on Effect of ShenXianShengMaiYe through Duodenal Administration on Rabbit Model with Sick Sinus Syndrome

用日本大耳白兔４０只，随机分为模型组，参仙升脉液大、中、小３个剂量组和心宝组。用２０％甲醛液外敷窦房结区制作病态窦房结综合征（病窦）模型，观察参仙升脉液十二指肠给药对家兔病窦模型的心率和窦房结电生理指标的变化。结果表明参仙升脉液可以明显提高窦性心率，明显缩短窦房结传导时间（ＳＡＣＴ）及窦房结恢复时间（ＳＡＲＴ），且大剂量组较心宝组效果显著。

Divide 40 Japanese large-earring white rabbits randomly into model group, large, medium, and small dosage of Shenxianshengmaiye (SXSM) group and Xinbao group. Create the model with sick sinus syndrome by external application of 20% methanal on the sino-atrial node. Observe the changes of heart rate and electro-physiological index of sinoatrial node. The results show that SXSM can markedly increase the sinus rhythm, shorten the sino-atrial conduction time (SACT) and sino-atrial reserve time (SART). And the effect of large dosage group was more obvious than Xinbao group.