乙肝母婴阻断后婴儿静脉血乙型肝炎五项指标的实验室检测分析

Laboratory Detection and Analysis of Five Serological Markers of Hepatitis B in Infant Venous Blood after PMTCT

目的:研究乙型肝炎病毒母婴阻断后的临床效果.方法:乙型肝炎血清标志物阳性的116例孕妇母婴阻断后婴儿一岁时,采集静脉血,用MEIA法与ELISA法分别检测乙型肝炎五项指标并进行对比研究.结果:116例婴儿静脉血ELISA法检测结果为:抗-HBs(+)比例为72.4%,用MEIA法检测:抗-HBs(+)比例为73.3%;两种方法检测无显著差别(P>0.05).结论:HBV母婴垂直传播的发生率很高,母亲及婴儿乙型肝炎免疫球蛋白(HBIG)联合乙肝疫苗注射可显著提高HBV母婴传播阻断效果.

Objective：To investigate the clinical effect of prevention of mother-to-child transmission（PMTCT） of hepatitis B.Methods：116 pregnant women whose hepatitis B virus serological markers positive were performed PMTCT.When babies were one year old,collecting babies venous blood,using MEIA method and ELISA method to detect the five indicators of hepatitis B respectively and comparing the detecting results. Results：The detecting results of 116 infants by ELISA assay：the positive ratio of anti-HBs（＋）was 72.4%, by MEIA assay：the positive ratio of anti-HBs（＋）was 73.3%,there was no significant difference between the two methods（P0.05）.Conclusion：The incidence of HBV vertical transmission is very high,mother-baby and infant injection hepatitis B immunoglobulin（HBIG）combined with hepatitis B vaccine can significantly improve the interrupting effect of HBV transmission from mother to baby.