通脉益智胶囊对小鼠反复脑缺血再灌流后行为学的影响

Effects of TongMaiYiZhi Capsule on Mouse Behaviors under Repeated Cerebral Ischemic Reperfusion Condition

为了观察通脉益智胶囊对小鼠反复脑缺血再灌流后行为学的影响，我们将４０只小鼠分为４组，经反复脑缺血再灌加降血压法造模后，分别给予生理盐水、通脉益智胶囊、喜德镇灌胃，术后进行跳台、水迷宫实验测试。结果显示，模型组小鼠潜伏期缩短、游全程时间延长、错误次数增多；通脉益智胶囊组能使上述指标好转，统计学上有显著差异。本实验证实了反复脑缺血再灌流明显造成了小鼠学习、记忆功能障碍，而通脉益智胶囊可对抗此障碍，提高学习、记忆能力。

mice models with vascular dementia (VD) were divided into 4 groups and administered respectively with 0.9% NS, TongMaiYiZhi capsule (TMYZ) and hydergine. Observe their behaviors in step-down avoidance test and water-maze test. Results: The mouse's performance in the water labyrinth was obviously affected. The whole distance swimming time was prolonged and mistakes increased. TMYZ can improve the above indice and there was remarkable difference in statistics. It proved that TMYZ could strengthen the mouse in learning and memory.