期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

促红细胞生成素对脑缺血再灌注大鼠神经保护作用的研究 被引量：1

下载PDF
导出
摘要 研究发现,促红细胞生成素（EPO）作为一种多功能的生长因子,在各种中枢神经系统疾病中具有重要的神经保护作用[1]。外源性EPO通过与其特异性受体结合,对缺血再灌注引起的脑组织损伤发挥神经保护作用,可能与抑制神经细胞凋亡有关。
作者 郭丽君 袁慧欣 乔振华
机构地区 山西医科大学第二医院血液科 武警山西总队医院内分泌科 武警山西总队医院院部
出处 《中国药物与临床》 CAS 2011年第4期402-404,I0001,共4页 Chinese Remedies & Clinics
关键词 脑缺血再灌注大鼠 促红细胞生成素 神经保护作用 中枢神经系统疾病 神经细胞凋亡 脑组织损伤 生长因子 受体结合
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献7

  • 1Sun Y,Zhou C,Polk P,et al. Mechanisms of erythropoietin-induced brain protection in neonatal hypoxia-ischemia rat model. J Cereb Blood Flow Metab, 2004,24(2) : 259-270.
  • 2Cerami A,Brines ML,Ghezzi P,et al. Effects of epoetin alfa on the central nervous system. Semin Oncol, 2001,28 (2) :66-70.
  • 3Bederson JB, Pitts LH,Tsuji M. Rat middle cerebral artery occlusion: evalution of the model and development of a neurologic examination. Stroke, 1986,20( 1 ) : 472-476.
  • 4Garcia JH,Wagner S,Liu KF,et al. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats statistical validation. Stroke, 1995,26: 627.
  • 5全伟,李铁林,陈光忠,吕建平,张昊,钟文军,陈颖东,陈凡帆.促红细胞生成素在狗脑血管痉挛发生中的作用机制研究[J].中华神经医学杂志,2006,5(4):366-368. 被引量：4
  • 6Deverau QL,Leo E,Stennicke HR,et al. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J, 1999,18 (19):5242- 5251.
  • 7Siegelin MD,Kossatz LS,Winekler J,et al. Regulation of XIAP and Smac/DIABLO in the rat hippocampus following transient fore-brain ischemia. Neurochem Int,2005,46(1) :41-51.

二级参考文献8

  • 1Liszczak TM,Varsos VG,Black PPM,etal.Cerebral arterial constriction after experimental subarachnoid hemorrhage is associatedwith blood components within the arterial wall[J].J Neurosurg,1983,58(1):18-26.
  • 2Celik M,Gokmen N,Erbayraktar S.et al.Erythropoietin prevents motor neuron apoptosis andneurologic disability in experimental spinal cord ischemic injury[J].Proc Natl Acad SciUSA,2002,99(4):2258-2263.
  • 3Pluta RM.Delayed cerebral vasospasm and nitric oxide:review,new hypothesis,and proposedtreatment[J].Pharmacol Ther,2005,105(1):23-56.
  • 4Lin CL,Jeng AY,Howng L,et al.ndothelin and subarachnoid hemorrhage-induced cerebralvasospasm:pathogenesis and treatment[J].Curr Med Chem,2004,11(13):1779-1791.
  • 5Kirchengast M,Luz M.Endothelin receptor antagonists:clinical realities and futuredirections[J].J Cardiovasc Pharmacol,2005,45(2):182-191.
  • 6Sakanaka M,Wen TC,Matsuda'S,et al.In vivo evidence that erythropoietin protects heuronfrom ischemic damage[J].Proc Natl Acad Sci USA,1998,95(8):4635-4640.
  • 7Chong ZZ,Lin SH,Kang JQ,et al.Erythropoietin prevents early and late neuronal demisethrough modulation of Aktl and induction of caspasel,3,and 8[J].J NeurosciRes,2003,71(5):659-669.
  • 8Ziv I,Fleminger G,DjaldettiR,et al.Increased plasma endothelin-1in acute ischemicstroke[J].Stroke,1992,23(7):1014-1016.

共引文献3

同被引文献25

  • 1徐晓娜,李广平.促红细胞生成素与心肌缺血再灌注损伤[J].中国心血管杂志,2007,12(3):227-228. 被引量：2
  • 2Caiola KJW. USE of erythropoietin in heart failare management[ J]. Ann Phamacother,2004 ,38 :2145 - 2149.
  • 3Van der Meer P, Groenveld HF, Januzzi JL Jr, et al. Erythropoietin treat- ment in patients with chronic heart failure:a meta-analysis [J]. Heart, 2009,95 : 1278 - 1279.
  • 4Zhang J, Wu Y ,Jin Yet al. Intravitreal injection of erythropoietin protects both retinal Vascalar and neuronal ceils in early diabetes [ J ]. Invest Ophthalmol Vis Sci ,2008,49:732 - 42.
  • 5Schmid JA,Birbach A. Ikappa B. Kinase beta(Ikkbeta/Ikkz/IKBKB) -a key molecule in signaling to the transcription factoy NF-Kappab [ J ]. Cytokine Growth Factor Rew, 2008,19 : 157 - 165.
  • 6Yamada M, Burke C, Colditz P, et al. Erythropoietin proteets against apoptosis and increases expression of non - neuronal cell markers in the hypoxia-injured developing brain[ J]. J Pothol,2011,224 : 101 - 199.
  • 7Keogh CL, Yu SP, Wei L. The effect of recombinant human erythropoie- tin on neurovasculature repair after focal ischemic stroke in neonatal rats [ J]. J Pharmacol Exp Ther,2007,322:521 - 528.
  • 8Zhang L, Chopp M, Zhang RL, et al. Erythropoietin amplifies stroke-in- duced digodendrogenesis in the rat[J]. Plos One,2010,5: e11016.
  • 9Kidd PM. Integrated brain restoratio sfter ischemic stroke-meddical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity [J]. Ahem Med Rev,2009, 14 : 14 - 15.
  • 10Xiong Y, Lu D, Qu C, et al. Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice[ J]. J Neurosurg,2008,109:510 - 521.

引证文献1

二级引证文献3

中国药物与临床
2011年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部