老年人颈动脉粥样硬化斑块形成与血管危险因素的相关性分析

Association between vascular risk factors and carotid plaque in the elderly

目的探讨老年人颈动脉粥样硬化斑块形成与血管危险因素的相关性。方法选择在我院行颈动脉超声检查的老年患者共305例,根据超声检查结果分为斑块组(212例)和对照组(93例)。每例患者均记录有无高血压、糖尿病史,测量空腹血糖、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及尿酸等,进行统计学分析。结果单因素分析显示,两组间高血压病史(62.26vs37.63)、糖尿病病史(52.83vs39.78)、血尿酸[(329.958±118.682)μmol/Lvs(265.270±137.118)μmol/L]、收缩压[(142.028±17.390)mmHgvs(135.467±15.823)mmHg]、脉压[(63.514±12.993)mmHgvs(58.511±11.217)mmHg)]、年龄[(71.854±6.037)岁vs(68.967±5.767)岁]差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,年龄、高血压及血尿酸与颈动脉粥样硬化斑块形成相关(P<0.05)。结论年龄、高血压及高血尿酸水平可能是颈动脉硬化斑块形成的独立危险因素。

Objective To investigate the vascular risk factors related to the carotid plaque in the elderly.Methods Three hundred and five cases were divided into carotid plaque group and control group by the results of carotid ultrasonography.Patients of the two groups were compared in the level of some possible risk factors including：hypertension,diabetes,serum lipids,uric acid,etc.Further multivariate regression analysis was performed to select the risk factors for carotid plaque.Results The mean age,The serum level of uric acid,the mean systolic blood pressure,the mean pulse pressure and the incidences of hypertension and diabetes were significantly higher in the patients with carotid plaque（P0.05）.Logistic regression analysis showed that age,the incidence of hypertension and the serum level of uric acid were associated with carotid plaque（P0.05）.Conclusions Age,the incidence of hypertension and high uric acid level are the possible independent risk factors for carotid plaque in the elderly.