珊瑚转化多孔羟基磷灰石复合rhBMP-2人工骨的动物实验研究

Effects of the composite of rhBMP2 and coralline hydroxyapatite in bone defect repair

目的：寻找新的骨代用材料。方法：采用珊瑚转化多孔羟基磷石（ＣＨＡ）作为移植物支架，用Ｉ型胶原作为ｒｈＢＭＰ－２的缓释载体及赋形剂，将三者复合制成新型人工骨，进行了大鼠标准颅骨缺损骨移植实验。结果：ＣＨＡ／胶原具有良好的生物相容性和骨引导作用。ｒｈＢＭＰ－２／ＣＨＡ／胶原具有骨引导和骨诱导双重特性，其成骨效应明显优于单纯ＣＨＡ／胶原植入。结论：该复合人工骨有可能成为临床修复骨缺损的有效材料。

Objective: To study the feasibility of rhBMP2hydroxyapatite composite for bone defect repair. Methods: A composite of coralline hydroxyapatite(CHA),used as bone graft supporting frame,human bone morphogenetic protein2(rhBMP2) and type I collagen,used as carrier of rhBMP2, was prepaired and transplanted into cranial defects of mice;the effects were observed. Result: CHA/collagen showed biocompatibility and osteoconductive activity;rhBMP2/CHA/collagen showed more osteoinductive and more osteoconductive than CHA/collagen. Conclusion: This combined artificial bone may be feasible for bone defect repair.