胃癌病人唾液中ABH血型物质测定及其临床意义

Determination and the Clinical Significance of ABH Blood Group Substance in the Saliva of the Patients with Gastric Cancer

本文采用唾液中的血型物质，能特异性的与相应抗体结合，从而抑制抗体与抗原凝集反应的中和试验方法，对已知ＡＢＯ血型健康人６０例，胃癌人３０例的血型物质效价进行了比较，胃癌病人手术前后的血型物质效价进行了比较，及低分化腺癌同其他类型的胃癌血型物质效价进行了比较。试验结果经统计学分析，正常人与胃癌病人血型物质的效价，胃癌病人Ａ型物质和Ｈ型物质较正常人显著升高，Ａ型Ｐ＜００１，Ｏ型Ｐ＜００５，胃癌病人手术后血型物质效价较术前，Ａ型下降显著Ｐ＜００１，Ｏ型与Ｂ型无差异，不同类型胃癌病人血型物质效价比较，Ａ型Ｐ＜００１，低分化腺癌与高分化腺癌比较，Ａ型物质与Ｏ型物质显著升高，Ｐ＜００１。以上结果提示：检测血型物质，其一可作为诊断胃癌病人的辅助指标。其二可作为Ａ型Ｏ型病人愈后跟踪调查。

According to that the blood group substance in saliva can specifically combine to it's corresponding antibody,the method of neutralization test was adopted to determine the differences in the concentration of the blood groop substance between 60 cases of healthy people whose blood types were known and 30 cases of patients with carcinoma of stomach,as well as the differences after and before operation in patients with gastric cancer,and also between patients with poorly differentiated gastric adenocarcinoma and patients with other pathologic types.The result was statistically analysised.The concentration of A type and H type blood group substance in patients with gastric cancer elevated significantly as contrast to those in healthy people (A type, P <0 01;O type, P <0 05).The concentration of blood group substance in patients of A blood type but not in patients of B or O blood type decreased obviously.The result indicates that concentrationes of A and H blood group substance in patients with poorly differentiated adenocarcinoma elevated significantly as compare to those in patients with the other pathologic types ( P <0 01).All the results suggest that determination of the blood group substance can be used as an auxiliary index of diagnosing the gastric cancer and also as a prognostic indicator for the patients of A and O blood type.