摘要
目的探讨大肠癌病人血清层粘连蛋白，Ⅳ型胶原含量与病情的关系。方法应用放射免疫技术测定了大肠癌患者血清层粘连蛋白（ＬＮ）及Ⅳ型胶原（ＣｏｌⅣ）含量。结果大肠癌患者血清ＬＮ、ＣｏｌⅣ含量明显高于对照组，相差非常显著（Ｐ＜００１）；淋巴结转移组血清ＬＮ及ＣｏｌⅣ含量明显高于无淋巴结转移组，两者相差显著（Ｐ＜００５）；血清ＬＮ含量中，ＤｕｋｅｓＣ期组高于ＤｕｋｅｓＢ期组，两者相差显著（Ｐ＜００５）；血清ＣｏｌⅣ含量由ＤｕｋｅｓＢ期至Ｄ期有逐渐升高趋势，且ＤｕｋｅｓＤ期组显著高于ＤｕｋｅｓＢ期组，两者相差显著（Ｐ＜００５）。结论提示血清ＬＮ、ＣｏｌⅣ含量变化与大肠癌细胞的浸润、转移等生物学行为密切相关。对判断其病情及预后可能具有一定的参考价值。
The contents of Laminin (LN) and Collagen type Ⅳ (ColⅣ) in serum were measured
by radioimmunoassay in patients with colorectal cancer.It was showed that the content of LN
and ColⅣ in cancer group was significantly higher than those in control group ( P <0 01),the
content of LN and ColⅣ in group with lymph node metastases was higher than those in group
without lymph node metastases ( P <0 05).The content of LN in Dukes C group was hight than
that in Dukes B group ( P <0 05).There was a tendency that the content of serum ColⅣ
increased with the advance of the Dukes clasification and content of serum ColⅣ in DukesD
group was higher than that in Dukes B group.This implies that the contents of the serum LN and
ColⅣ is closely related to the tumor invasion and metastases,and the assay of the LN and Col
Ⅳ in serum may be useful to the diagnosis of colorectal cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第4期284-285,共2页
Cancer Research on Prevention and Treatment
