期刊文献+

微乳作为经皮给药和其他给药载体的优势与局限性分析 被引量:1

下载PDF
导出
摘要 微乳(microemulsion,ME)是由水、油相、表面活性剂和助表面活性剂按适当的比例自发形成的一种透明或半透明的、低黏度、各向同性且热力学稳定的溶液系统。微乳属于胶体分散系统,其乳滴多为球形,大小均匀,外观透明或近似透明,经热压灭菌或离心也不能使之分层,按结构可分为油包水(W/O)型、水包油(O/W)型和双相连续型微乳。
作者 王晓红
机构地区 山西省肿瘤医院
出处 《山西医药杂志(上半月)》 CAS 2011年第4期366-368,共3页 Shanxi Medical Journal
  • 相关文献

参考文献10

  • 1Brime B, Molero G, Frutos P, et al. Comparative therapeutic efficacy of a novel lyophilized amphotericin B lecithin- based oil-water microernulsion and deoxycholate-amphotericin B in immunocompetent and neutropenic mice infected with Candida albicans. Eur J Pharm Sci, 2004, 22(5): 451- 458.
  • 2Paolino D, Ventura CA, Nistico S, et al. Lecithin microe mulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability. Int J Pharm, 2002, 244(1-2) : 21-31.
  • 3Mei Z, Chen H, Weng T, et al. Solid lipid Nano-particleand microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm, 2003, 56(2)189-196.
  • 4Damora ME,Dalmora SL,Oliveira AG. Inclusion complex of piroxicam with β-cyclodextrin and incorporation in cationic microemulsion: in vitro drug release and in vivo topical anti in-flammatory effect. Int J Pharm, 2001, 222(1):45-55.
  • 5Sintov AC, Bother S. Transdermal drug delivery using mi croemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems. Int J Pharm, 2006, 311(122): 55- 62.
  • 6Kreilgaard M. Dermal pharmacokinetics of microemulsion formulations determined by in vivo microdialysis. Pharm Res,2001,18(3) : 367-373.
  • 7Lee PJ,Langer R, Shastri VP. Novel microemulsion enhan eer formulation for simultaneous transdermal delivery of hy drophilic and hydrophobic drugs. Pharm Res, 2003, 20(2) 264-269.
  • 8Sintov AC, Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug hioavailability in vivo. J Control Release, 2004, 95(2) 173- 183.
  • 9Blanch GP, Castilloml R, Caja M. Stabilization of all translycopene from tomato by encapsulation using cyelodextrins. Food Chem, 2007, 105(4): 1335 1341.
  • 10Li L, Nandi I, Kim KH. Development of an ethyl laurate based micromulsion for rapid onset intranasal delivery of diazepam. Int J Pharm, 2002, 237(1-2) : 77-85.

同被引文献18

  • 1张先洲,祝红达,孟书舫,潘细贵.青藤碱微乳的制备及其体外经皮渗透研究[J].中国中药杂志,2007,32(19):2007-2010. 被引量:12
  • 2曹发吴.苦参碱微乳的研究[D].杨凌:西北农林科技大学,2007.
  • 3Kweon JH, Chi SC, Park ES. Transdemal delivery of diclofenac using microemulsions. Arch Pham Res, 2004,27(3) :351.
  • 4Zhao X, Liu JP, Zhang X, Li Y: Enhancement of trans- dermal delivery of theophylline using microemulsion ve- hicle. Int J Pharm2006,327:58 - 64.
  • 5Chen H, Chang X, Weng T,Zhao X, Gao Z, Yang Y, Xu H, Yang X:A study of microemulsion systems for transdermal delivery of triptolide. J Control Release 2004,98:427 - 436.
  • 6ZHANG Qz, JIANG XG,, JIANG WM. Preparation of nimodipine- loaded microemulsion for intranasal de- livery and evaluation on the targeting efficiency to the brain [J]. Int J Pharm,2004,275(1/2) :85 -96.
  • 7Lawrence M J, Rees GD. Mieroemulsion- based media as novel drug delivery systems. Ady Drug Deliv Rev. 2000,45:89 - 121.
  • 8Morgan TM, Reed BL, Finnin BC: Enhanced skin permeation of sex hormones with novel topical spray vehicles. J Pharm Sci. 1998,87:1213 -1218.
  • 9韩盈.丹皮酚微乳经皮给药系统的研究[D].上海:第二军医大学,2013.
  • 10应娜,林高通.微乳的研究进展及应用[J].海峡药学,2008,20(9):126-128. 被引量:11

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部