奥沙利铂联合卡培他滨治疗晚期及复发转移性胃癌的临床观察

Effect of combined oxaliplatin and capecitabine chemotherapy on advanced and recurrent gastric cancer

目的观察奥沙利铂联合卡培他滨治疗晚期及复发转移性胃癌的近期疗效及患者不良反应。方法对56例晚期及复发转移性胃癌患者采用奥沙利铂联合卡培他滨治疗，对其近期疗效及不良反应进行回顾性分析。结果56例患者中完全缓解4例（7．1％），部分缓解26例（46．4％），稳定20例（35．7％），进展6例（10．7％），总有效率（RR）53．6％。中位缓解期7．8个月，中位生存期11．3个月。主要不良反应为恶心、呕吐、腹泻、手足综合征、外周神经毒性、血红蛋白及白细胞减少。不良反应较轻，多为I～Ⅱ度，大部分患者可耐受。结论奥沙利铂联合卡培他滨治疗晚期及复发转移性胃癌有较好的疗效，不良反应较轻，是晚期胃癌患者较为理想的化疗方案。

Objective To investigate the therapeutic effect and side effect of combined capecitabine with oxaliplatin on advanced and recurrent gastric cancer. Methods 56 patients with advanced and recurrent gastric cancer were treated with combined oxaliplatin and capccitabine chemotherapy, and the therapeutic effect and side effect were analyzed retrospectively. Results Among all 56 patients treated with combined oxaliplatin and eapeeitabine chemotherapy, 4 patients （7.1%） were complete remission, 26 patients （46.4 %） were partial remission, 20 patients （35.7 %） were stabilization, 6 patients （10.7 %） were progression, and the response rate was 53.6 %. The median remission time was 7.8 months, and the median survival time was 11.3 months. The main side effects were nausea and vomiting, diarrhea, hand-foot syndrome, peripheral nerve toxicity, transaminase increasing and leuco cytopenia, however, the side effects were mainly grade I and Ⅱ which could he tolerated by patients. Conclusion The combined oxaliplatin and capecitabine chemotherapy is an effective method and has better tolerance in treatment of advanced gastric cancer and is well worth clinical application.