睾丸Leydig细胞瘤5例报告并文献复习

Report of 5 cases of Leydig cell tumor of the testis and literature review

目的探讨睾丸Leydig细胞瘤的临床病理特点。方法总结5例睾丸Leydig细胞瘤患者的临床病理资料并复习相关文献。结果 3例患者行根治性睾丸切除术;1例患者术中经腹股沟阻断精索切除病灶,并行快速冷冻病理检查证实为Leydig细胞瘤,行保留睾丸手术;1例患者行经阴囊的睾丸切除术。术后病理均证实为Leydig细胞瘤。患者术后平均随访32个月,未见肿瘤复发或转移。结论睾丸Leydig细胞瘤临床罕见,对于怀疑为Leydig细胞瘤的睾丸小肿瘤患者,我们推荐术中冷冻病理检查。对于冷冻病理为良性特征的小体积Leydig细胞瘤,特别是儿童应首选保留睾丸的手术治疗。

Objective To investigate the clinicopathological characteristics of Leydig cell tumor（LCT）of the testis.Methods5 cases of Leydig cell tumor of testis was reportcd and related literatures were reviewed.ResultsOf the 5 patients with LCT,3 patients were treated with radical orchiectomy;1 patient lesion was resected via an inguinal approach with spermatic cord clamping and sent for frozen section examination,the frozen section examination were diagnosed as LCT and he was underwented testis sparing surgery;1 patient was treated with orchiectomy via the scrotum approach.Definitive pathological examination confirmed LCT in all cases.After a mean follow-up of 32 months,neither recurrence nor metastases have been detected.ConclusionsLCT of the testis is a rare tumor.We recommend the use of frozen-section analysis in patients who present with a small testis mass suspicious for LCT.Organ-sparing surgery should be the preferred approach to small LCT with benign characteristics,especially in boys.