摘要
目的:探讨药品不良反应(ADR)的发生情况,为临床用药提供参考。方法:对山东省肥城矿业中心医院上报的545例药品不良反应分别从年龄、给药途径、药品种类、ADR临床表现等方面进行分析和评价。结果:545例药品不良反应共涉及9大类药品,其中抗感染药引起的ADR最多为288例,占52.84%;给药途径中静脉用药引起的ADR为340例,占62.38%;临床所累及器官和(或)系统以皮肤及其附件最常见,其次是胃肠道反应,最严重的是死亡、过敏性休克、高热等。结论:必须重视药品不良反应监测工作,加强药师与临床的沟通交流,减少或避免药品不良反应的发生。
OBJECTIVE: To investigate the occurrence of the adverse drug reactions(ADRs) so as to provide reference for clinical drug use.METHODS: We analyzed 545 ADR cases with regard to patients’ age,route of administration,drug category and clinical manifestations of ADRs etc.RESULTS: Of the total 545 ADR cases,9 major categories of drugs were involved;the anti-infectives took the lead with 288 cases(52.84%);intravenous drip infusion took the lead with 340 cases(62.38%).Lesions of skin and its appendages were the most common manifestations,followed by gastrointestinal tract reactions.Death,allergic shock and fever etc were the most serious ADR.CONCLUSION: It is urgent to tighten ADR monitoring and enhance communication between pharmacists and clinicians to reduce or avoid adverse drug reactions.
出处
《中国医院用药评价与分析》
2011年第4期370-372,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
报告
分析
Adverse drug reaction
Report
Analysis