MLH1基因415位点G→C基因突变与胃癌发生的关系

A Study on Relationship between MLHl Gene 415 Locus G— G Mutation and Stomach Cancer

目的:探讨MLH1基因415位点G→C基因多态性与胃癌发生的关系。方法:采用PCR-限制性长度片段多态性分析法检测2006年1月至2008年12月61例胃癌患者和49名正常人群外周血MLH1415位点基因突变情况。结果:散发胃癌患者MLH1基因415位点C/C基因型频率明显高于正常人群,P<0.05。结论:MLH1基因415位点G→C突变是我国散发胃癌的遗传易感因素。

Objective： To explore the relationship between MLH1 gene 415 locus G→G mutation and stomach cancer. Methods： MLH1 gene 415 locus mutalion of 61 patients with gastric cancer and 49 normal people were extracted from peripheral blood from Jan 2006 to Dec 2008. Gene mutation was analyzed by PCR-RFLP. Results： The frequency of MLH1 gene C/C genotype was significantly higher in patients with gastric cancer than that in normal people, P〈0.05. Conclusion： MLH1 gene 415 locus G→C nmtation may be a genetic susceptibility to sporadic gastric cancer in Chinese.