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紫草素对大鼠离体胸主动脉舒张作用及机制研究 被引量:2

Vasodilative effect of shikonin on excised thoraic aorta annulations in rats
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摘要 紫草为紫草科植物的干燥根,性甘寒清热,入心肝二经,有凉血活血解毒清热的作用,提示其可能具有作用心血管系统的特性。紫草的有效化学成分主要包括脂溶性很强的萘醌类色素和水溶性成分[1-2],其中。
出处 《中国药理学通报》 CAS CSCD 北大核心 2011年第4期587-588,共2页 Chinese Pharmacological Bulletin
基金 新疆建设兵团重点科技攻关计划(No2010GG36)
关键词 紫草素 舒血管作用 血管内皮 环氧合酶信号通路 鸟苷酸环化酶信号通路 钙通道 shikonin vasodilative effect endothelium cyclooxygenase signaling pathway guanylate cyclase signaline pathway calcium channel
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  • 1Wang G J, Wu XC, Chen CF, et al. Vasorelaxing action of rutaecarpine: ef{ects o: rutaecarpine on calcium channel activities in vascular endothelial and smooth muscle cells[J]. J Pharmacol Exp Ther , 1999 ,289(3) :1237-1244.
  • 2Kim EY, Kim JH, Rhyu MR. Endothelium-inde- pendent vasorelaxation by ligusticum wallichii in i- solated rat aorta: comparison of a butanolie fraction and tetramethylpyrazine, the main active component of ligusticum wallichii [J]. Biol Pharm Bull, 2010, 33(8) :1360-1363.
  • 3Kitazono T, Faraci FM, Taguchi H, et al. Role of potassium channels in cerebral blood vessels[J]. Stroke, 1995,26(9) : 1713 - 1723.
  • 4Peng W, Hucks D, Priest RM, et al. Ligustrazine- induced endothelium-dependent relaxation in pulmo- nary arteries via an NO-mediated and exogenous L -arginine-dependent mechanism [J]. Br J Pharma- col ,1996, 119(5):1063-1071.
  • 5Sobey CG. Potassium channel function in vascular disease[J]. Arterioscler Thromb Vasc Biol, 2001,21 (1) :28-38.
  • 6Stiles GL, Caron MG, Leftkowitz RJ. 13-Adrenergie receptors: biochemical mechanisms of physiological regulation[J]. Physiol Rev, 1984, 64(2) : 661-743.
  • 7Coleman HA, Tare M, Parkington HC. Endothelial potassium channels, endothelium-dependent hyper- polarization, and the regulation of vascular tone in health and in disease[J]. Clin Exp Pharmacol Physi- oi,2004 ,31(9) :641-649.
  • 8Absi M ,Burnham MP ,Weston AH , et al. Effects of methyl : cyclo- dextrin on EDHF responses in pig and rat arteries: association between SKCa channels and caveolin-rich domains[J]. Br J Pharma- col, 2007,151 (3) : 332- 340.
  • 9Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle[J]. Am J Physiol,1995,268(4 Pt 1) :C799- C822.
  • 10Sheng JS, Ella S, Davis, MJ, et al. Openers of SKCa and IKCa channels enhance agonist evoked endothelial nitric oxide synthesis and arteriolar vaso- dilation [J]. FASEB J, 2009,23 (4) : 1138 - 1145.

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