手术治疗口腔颌面部恶性黑色素瘤18例临床分析

The outcomes of 18 cases with oral and maxillofacial malignant melanoma after different surgeries

目的探讨口腔颌面部恶性黑色素瘤的诊断和治疗。方法回顾分析18例口腔颌面部恶性黑色素瘤临床资料。按治疗方式,18例患者的分为三组:A组5例,病灶扩大切除+淋巴清扫;B组6例,病灶扩大切除+淋巴清扫+化疗;C组7例,病灶扩大切除+淋巴清扫+化疗+免疫治疗。随访5年以上。结果术后随访结果:A组3年生存2例,5年生存为0;B组3年生存3例,5年生存1例;C组3年生存5例,5年生存3例。结论临床检查和病理有助于早期诊断。恶性黑色素瘤预后较差,外科手术+联合化疗+免疫治疗的综合治疗可取得较好的预后。

Objective To investigate the outcomes of 18 cases with oral and maxillofacial malignant melanoma after different surgeries.Methods Data of 18 patients with maxillofacial malignant melanoma were retrospectively analyzed.On the bases of treating regimen,the patients were divided into three groups of A（5 cases,radical resection plus expanded neck surgery）,B（6 cases,surgery as for group A plus chemotherapy） and C（7 cases,treated as for group B plus immunotherapy）.The patients were followed up for more than 5 years.Results The results of follow-up were 3-year survival in 2 cases and no 5-year survival case in group A,3-year survival in 3 cases and 5-year survival in one case,and 3-year survival in 5 cases and 5-year survival in 3 cases.ConclusionClinical examination and pathological biopsy are healpful for early diagnosis of melanoma.The prognosis of malignant melanoma is poor,which can be improved by comprehensive treatments with surgery,chemotherapy and immunotherapy.