左奥硝唑-氯化钠注射液治疗口腔厌氧菌感染的疗效

Efficacy of levornidazole-sodium chloride injection in treating oral anaerobic infections

目的评价左奥硝唑氯化钠注射液治疗口腔厌氧菌感染的临床疗效与安全性。方法采用随机、双盲、平行对照研究。入组60例口腔厌氧菌感染患者均分为两组,分别静脉滴注左奥硝唑-氯化钠注射液（试验组）或奥硝唑-氯化钠注射液（对照组）,剂量均为0.5 g,每日2次,3~5 d为1个疗程。评价药物疗效及安全性。结果试验组患者用药后痊愈率96.67%,对照组为90.00%（P〉0.05）。试验组细菌清除率为100.00%,对照组为83.33%（P〉0.05）。试验组不良反应发生率为0,明显低于对照组的23.33%（P〈0.01）。结论左奥硝唑治疗口腔厌氧菌感染安全有效。

Objective To evaluate the clinical efficacy and safety of levornidazole-sodium chloride injection against oral anaerobic infections.Methods Sixty patients with periodontitis and pericoronitis were enrolled in a randomized,double blind,parallel controlled trial,who were divided into two groups with 30 cases each.The patients in test group were treated by levornidazole-sodium chloride injection 0.5 g infused IV.twice a day for 3 to 5 days and those in control group were treated by ornidazole-sodium chloride injection in the same dose as in test group.Clinical efficacy and safety were compared.Results The cure rate was 96.67% for test group and 90.00% for control group（P0.05）.The bacterial eradication rate was 100% for test group and 83.33% for control group（P0.05）.The incidence rate of side effects was zero for test group,which was 23.33% for control group（P0.01）.Conclusion Levornidazole has the same clinical efficacy and safety as ornidazole-sodium chloride injection in treating oral anaerobic infections.