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美国食品药品监督管理局批准贝利单抗治疗系统性红斑狼疮 被引量:4

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摘要 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种慢性多系统受累的自身免疫性疾病。其发病机制可能是遗传和环境因素等共同作用导致患者免疫平衡紊乱,T细胞数量和功能缺陷、自身反应性B细胞过度激活、自身抗体和炎性介质大量产生和释放,最终摧毁多个靶器官。
作者 石坚 刘湘源
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2011年第4期261-261,共1页 Chinese Journal of Rheumatology
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  • 1温成平,范永升,李永伟,吴华香,李学铭,王新昌,曹灵勇.中西医结合治疗系统性红斑狼疮的增效减毒作用研究[J].浙江中医药大学学报,2007,31(3):305-309. 被引量:41
  • 2Mackay F, Schneider P. Cracking the BAFF code [ J ]. Nat Rev Im- munol,2009,9 (7) :491-502.
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  • 4Ramanujam M. Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice[J]. Arthritis Rheum,2010,62(5) :1457-1468.
  • 5Jacob CO. Paucity of clinical disease despite serological autoirranunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice de- ficient in BAFF[J]. J Immunol,2006,177(4) :2671-2680.
  • 6Liu Z, A Davidson. BAFF inhibition: a new class of drugs for the treatment of autoimmunity [ J ]. Exp Cell Res, 2011,317 ( 9 ) : 1270- 1277.
  • 7Halpern WG. Chronic administration of belimumab, a BLyS antago- nist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys : pharmacokinetic, pharmacodynamic and toxicologic effects[ J]. Toxicol Sci,2006,91 (2) :586-599.
  • 8Auyeung-Kim DJ. Developmental and peri-postnatal study in cyno- molgus monkeys with belimumab, a monoclonal antibody directed a- gainst B-lymphocyte stimulator [ J ]. Reprod Toxicol, 2009,28 ( 4 ) : 4.4-3 -455.
  • 9Wallace DJ. A phase II , randomized, double-blind, placebo-con- trolled, dose-ranging study of belimumab in patients with active sys- temic lupus erythematosus [ J ]. Arthritis Rheum, 2009,61 ( 9 ) : 1168-1178.
  • 10Navarra SV. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus : a randomised, placebo-controlled, phase 3 trial[ J]. Lancet,2011,377 (9767) :721-731.

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