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microRNA与免疫调控 被引量:8

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摘要 微小RNA(microRNA)又简称miRNA,是一类长约21~25个核苷酸的小分子RNA,能与特定的信使RNA靶向结合,在转录后水平调控基因表达。越来越多的证据表明,miRNA可通过靶向免疫系统中关键信号转导分子的表达,从而在多个环节上参与调控机体固有免疫反应和适应性免疫反应。已经发现,miRNA参与调节肿瘤、类风湿关节炎、多发性硬化症等相关免疫性疾病。因此miRNA可能成为治疗免疫性疾病的一个侯选靶点。
出处 《现代免疫学》 CAS CSCD 北大核心 2011年第2期89-92,共4页 Current Immunology
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同被引文献144

  • 1钱琤,邓安梅,仲人前.miRNA与固有免疫[J].现代免疫学,2008,28(2):161-164. 被引量:1
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  • 3任美玉,吴欣怡.Toll样受体的研究进展[J].现代免疫学,2006,26(4):340-342. 被引量:24
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