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TGF-β在CD4^+CD25^+调节性T细胞和Th17细胞分化中的调控 被引量：6

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摘要 目前认为CD4+CD25+调节性T细胞(regulatory Tcells,Treg)和Th17细胞是区别于Th1和Th2外的另一组重要的T细胞功能亚群,在自身免疫中发挥相反的作用,且两者之间又存在密不可分的联系。Foxp3是在Treg分化成熟和功能发挥中起关键作用的转录因子,RORγt则是Th17细胞分化的特异性转录因子。但是新近研究发现后者可由TGF-β诱导产生,因此本文就TGF-β在Treg和Th17分化中的调控作一综述。
作者 赵燕 沈立松
机构地区 上海交通大学医学院附属新华医院检验科
出处 《现代免疫学》 CAS CSCD 北大核心 2011年第2期156-159,共4页 Current Immunology
基金 上海市科委基础研究重点项目(07JC14045)
关键词 TGF-Β FOXP3 RORΓT CD4+CD25+调节性T细胞 TH17细胞
分类号 R392.12 [医药卫生—免疫学]
  • 相关文献

参考文献22

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二级参考文献10

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共引文献5

同被引文献76

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引证文献6

二级引证文献18

现代免疫学
2011年 第2期

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