1Krieg AM, YiAK, MatsonS, etal. CpG motifs in bacterial DNAtrigger direct B-cell activation[J]. Nature, 1995,374: 546-549.
2Dalpke A, Zimmermann S, Heeg K. CpG DNA in the pre vention and treatment ofinfetions[J]. Bio Drugs, 2002,16: 419 -431.
3Jahrsdorfer B, C-eorge J. CpG oIigodeoxynueleotides as im munotherapyincancer[J]. Update CancerTher, 2008.3:27- 32.
4Harandi AM, Eriksson K, Holmgren J. A protective role of locally administered immunoatirnulatory CpG oligodeoxynu cleotide nucleotide in a mouse model of genital herpes inlet tion[J]. J Virol, 2003,77:953- 962.
5Vollmer J, Krieg AM. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists [J]. Adv Drug Deliv Rev, 2009,61 : 195-204.
6Dohause N, Helm M, Pritschet K, etal. Differential effects of P-class versus other CpG oligodeoxynucleotide c/asses on the impaired innate immunity of plasmacytoid dendritic cells in HIV type 1 infection[J]. AIDS Res Retroviruses, 2010, 26:161 -171.
7VollmerJ, WeeratnaR, PayetteP, etal. Characterization of three CpG oligodeoxynucleotide classes with distinct immu nostimulatory activities[J]. Eur J Imrnunol, 2004,34..251 -262.
8Knuefermann P, Schwederski M, Velten M, et al. Bacterial DNA induces myocardic inflammation and reduces cardiomyo cyte contractility: role of toll like receptor 9[J]. Cardiovasc Res, 2008,78:26 -35.
9Barton GM, Medzhitov R. Toll like receptor signaling path ways[J]. Science, 2003,300:1524 -1525.
10Gelman AE, LaRosa DF, Zhang J, et al. The adaptor mole cule MyD88 activates PI 3kinase signaling in CD4 ^+ T cells and enables CpG oligodeoxynucleotide mediated costimulation [J]. hnmunity, 2006,25:783 -793.
二级参考文献22
1Hemmi H, Kaisho T, Takeda K, et al. The roles of Toll-like receptor 9, MyD88 and DNA-dependent protein kinase catalytic subunit in the distinct CpG DNA on dendritic cell subsets[J]. J Immunol, 2003,170(6):3059-3064.
2Krug A, Rothenfusser S, Selinger S, et al. CpG-A oligonucleotides induce a monocyte-deprived dendritic cell-like phenotype that preferentially activates CD8 T cells[J]. J Immunol, 2003,170(7):3468-3477.
3Weiwen J, Reich CF, You D, et al. Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis[J]. Biochem Biophys Res Commun, 2004,318(1):60-66.
4Kerkmann M, Rothenfusser S , Hornung V, et al. Activation with CpG-A and CpG-B oligonucletides reveals two distinct regulatory pathways of type Ⅰ IFN synthesis in human plasmacytoid dendritic cells[J]. J Immunol, 2003,170(9):4465-4474.
5Rothenfusser S, Tuma E, Endres S, et al. Plasmacytoid dendritic cells: the key to CpG[J]. Human Immunol, 2002, 63(12):1111-1119.
6Agrawal A, Lingappa J, Leppla SH, et al. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin[J]. Nature,2003,424(6946):329-334.
7Arpinati M, Chirumbolo G, Urbini B, et al. Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation[J]. Transplant Immunol,2003,11(3-4):345-356.
8Briere F, Bendriss-Vermare N, Delale T, et al. Origin and filiation of human plasmacytoid dendritic cells[J]. Human Immunol,2002,63(12):1081-1093.
9Larsson M, Beignon AS, Bhardwaj N. DC-virus interplay: a double edged sword[J ]. Semin Immunol, 2004,16(3),147-161.
10Vollmer J, Weeratna R, Payette P, et al. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities[J]. Eur J Immunol, 2004,34(1):251-262.
7Zhu Z, Zhu S, Guo X, et al. Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large- scale outbreaks from 2008[J]. Virol J, 2010,7: 300-306.
8McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance[J]. FEMS Mi- erobiol Rev, 2002,26:91-107.
9Liua CC, Choua AH, Lien SP. Identification and character- ization of a cross-neutralization epitope of Enterovirus 71[J]. Vaecine, 2011,29:4362-4372.
10Orjan. Strannegard CJ, Svennerholm B. A study of the cellular immune response to enteroviruses in humans: Identifica- tion of cross-reactive T cell epitopes on the structural proteins of enteroviruses[J]. J Gen Virol, 1996,77:2097-2108.