摘要
为探讨NSCLC中PDGF-BB、Podoplanin的表达与淋巴管生成的关系,用免疫组化法,检测80例NSCLC和20例癌旁正常肺组织中PDGF-BB、Podoplanin的表达;计数LMVD,结合临床病理资料统计分析。结果PDGF-BB、Podo-planin在NSCLC中存在高表达(P<0.05);阳性表达组LMVD较阴性表达组高(P均<0.05)。因此,PDGF-BB、Podo-planin在NSCLC癌细胞上存在高表达,并且与肿瘤淋巴管的生成密切相关。
To detect the expression of PDGF-BB,Podoplain in non-small lung cancer,and to evaluate the relationship of lymphangiogenesis,applying immunohistochemical method,lymphatic vessels and expressions of PDGF-BB and Podoplanin were detected in 80 NSCLC and 20 adjacent normal tissues,and the lymphatic micro-vessel density（LMVD） was counted.The relationship of PDGF-BB and Podoplanin to LMVD and the clinicopathological features were then analyzed.The expressions of PDGF-BB and Podoplanin in NSCLC were both higher than that of adjacent normal tissues.LMVD was significantly higher with PDGF-BB-or Podoplanin-positive expression than those with negative expression（both P0.05）.Therefore,in non-small cell lung cancer,expressions of PDGF-BB and Poplanin can promote lymphangiogenesis.
出处
《医学与哲学（B）》
2011年第4期62-64,共3页
Medicine & Philosophy(B)
基金
济南市科技明星计划资助课题
项目编号:济青科合字2007第1-115号
