甘露聚糖肽胶囊联合0.5%鬼臼毒素酊治疗尖锐湿疣的临床疗效观察

The Clinical Efficacy of Mannatide Capsule Combined with Podophyllotoxin Tincture in Treatment of Condyloma Acuminatum

目的评价甘露聚糖肽联合鬼臼根树脂溶液治疗尖锐湿疣的有效性与安全性。方法将126例入选病例按照随机数字表随机分为两组。治疗组63例,给予0.5%鬼臼毒素酊的同时加服甘露聚糖肽胶囊;对照组63例,仅给予0.5%鬼臼毒素酊。1周为1疗程,用药不超过5个疗程,疣体完全消退者继续随访至第18周以观察复发情况。结果 (1)痊愈率:观察组与对照组第1、2、3、4周的痊愈率分别为29.03%、26.22%,40.32%、32.78%,80.6%、62.3%,90.3%、73.78%,其中第3、4周两组比较具有统计学差异(P<0.05)。(2)复发率:观察组与对照组在第6周的复发率分别为8.06%和6.55%,第12周的复发率分别为9.67%和29.5%,第18周的复发率分别为9.67%和37.7%,其中第12、18周两组复发率差异具有统计学意义(P<0.05)。(3)副反应:经随访观察,两组发生了红斑、水肿、糜烂、灼热、疼痛、瘙痒、溃疡、脱屑等不良反应,观察组在红斑、水肿、糜烂、溃疡的发生率与对照组差异具有统计学意义(P<0.05),观察组低于对照组。结论甘露聚糖肽联合0.5%鬼臼毒素酊治疗尖锐湿疣疗效好、复发率低、不良反应较少。

Objective To further assess the efficacy and safety of combine therapy of mannatide capsule and Podophyllotoxin Tincture in the treatment of CA. Methods 104 patients with CA were randomly divided into 2 groups according to random number table. The control group were given 0.5% PodophyUotoxin Tincture and the observation group were treated with mannatide capsules on the basis of control group. Results （1）Cure rate：the cure rate of observation and control groups were 29.03%,26.22%;40.32%,32.78%;80.6%, 62.3%;90.3%,73.78% respectively in the beginning 4 weeks,and it has difference on week 3,4 between the two groups（P〈0.05）.（2） Relapse rate：the relapse rate of two groups were 8.06%,6.55%;9.67%,29.5%;12.9%,37.7% respectively,with difference between the two groups on week 12,18. （3）AD ： The two groups occurred, erythema, edema, erosion, scorching, ache, pruritus, ulcer, desquamation, etc. ; and the incidence of erythema,edema,erosion,ulcer in observation group was smaller than the control group. Conclusion Combine therapy of mannatide capsule and 0.5% Podophyllotoxin Tincture was safe and effective for the treatment of CA.