摘要
目的了解临床金黄色葡萄球菌(SA)的感染情况及其对常用抗生素的耐药情况,以便指导临床合理用药。方法对我院2008年7月～2010年6月间从临床分离的SA进行MRSA鉴定,并分析其是否产生β-内酰胺酶及其对一些常用抗生素的敏感性。结果共分离到145株SA,其中MRSA 101株,占SA的69.6%;145株SA中有80株产生β-内酰胺酶,占55.17%,MRSA产生β-内酰胺酶的百分率明显高于MSSA(P<0.05);101株MRSA对青霉素G、氨苄青霉素、头孢塞吩、头孢唑啉的耐药率均为100%;MRSA对红霉素、庆大霉素、阿奇霉素、氯霉素、四环素和利福平的耐药率明显高于MSSA(P<0.05)。环丙沙星和万古霉素对MRSA和MSSA都有较好的抗菌活性。结论 MRSA已成为医院感染的重要病原菌,且MRSA对多种抗生素具有较高的耐药性,环丙沙星和万古霉素是临床治疗MRSA和MSSA感染的首选药物。
Objective To investigate the infection status of staphylococcus aureus and analyze their resistance to antibiotics to guide the clinical reasonable application of medicines. Methods MRSA identification was practiced for Staphylococcus aureus isolated from July,2008 to June,2010 in the national traditional Chinese medicine hospital of Sangzhi county. The resistance to antibiotics and whether they produce β-lactamase were analyzed. Results A total of 145 strains Staphylococcus aureus,including 101 strains MRSA were isolated. Among them,80 strains produce β-lactamase（55.17%）,and the percentage of MRSA of producing β-1actamase was remarkably higher than that of MSSA （P〈0.05）.The resistance rate of MRSA to Penicillin G,Ampicillin,Cefalotine and Cefazolin were 100%. The resistance rates of MRSA to Erythromycin,Gentamycin,Azithromycin,chloramphenicol,tetracycline and Rifampicine were higher than those of MSSA （P〈0.05）.Vancomycin and Ciprofloxacin had good activities to MRSA and MSSA. Conclusion MRSA has becomed important pathogen in hospital and shows serious multiple resistance.Vancomycin and Ciprofloxacin are the drugs of the first choice for clinically treatment to MRSA and MSSA infections.
出处
《中国现代医生》
2011年第11期113-114,116,共3页
China Modern Doctor
