树突状细胞引流淋巴结归巢的研究进展

Progress in the process of dendritic cells homing to draining lymph nodes

树突状细胞(dendritic cells,DCs)是目前已知的体内功能最强的专职性抗原提呈细胞(professional antigen-present-ing cells,pAPC),在引发和调节机体的免疫反应中起着重要作用。树突状细胞最重要的功能是摄取、加工处理、提呈抗原,并刺激初始T细胞(naive T cells)活化、增殖,从而激发机体的免疫应答。DCs这一功能是在体内迁移过程中发挥的,其中DCs归巢至引流淋巴结被认为是激发免疫应答的关键步骤之一。本文将就近年来DCs归巢至引流淋巴结的研究进展作一综述。

Dendritic cells（DCs） are very potent antigen-presenting cells and play critical roles in regulating immune responses.DCs have the unique ability to take up and present Ag and to trigger primary immune responses,for the induction of the immunological tolerance,as well as for the regulation of the T cell-mediated immune response.In this complex process,DCs homing to draining lymph nodes is considered to be a critical initial step.Here,we review recent study progress of DCs homing to draining lymph nodes.