胸腔积液CA125检测的临床意义

Clinical significance of pleural effusion CA125 inspection

目的探讨胸腔积液CA125检测的临床意义。方法选择2010年1月至2010年10月在我院住院的胸腔积极患者500例,所有患者在入院后第1次胸腔积液穿刺标本。经过临床和病理确诊后对症治疗2～3周后,再次收集胸腔积液,进行CA125水平检测。结果炎性胸腔积液患者血清和胸腔积液中的CA125水平增加不显著,与及癌性和结核性性胸腔积液组相比,差异有统计学意义(P<0.05),结核性和癌性胸腔积极患者的血清和胸腔积液的CA125水平都显著升高,两者差异无统计学意义(P>0.05),而且胸腔积液中的CA125水平略高于血清。结核性胸腔积液患者与自身治疗前比较显著下降(P<0.01);恶性胸腔积液患者与自身治疗前比较无统计学意义(P>0.05),而且胸腔积液中的CA125下降幅度比血清较慢。结论 CA125可以作为诊断和治疗结核性胸腔积液的观察指标。

To explore the clinical significance of pleural effusion CA125 inspection,500 patients with pleural effusion were recruited.All patients underwent paracentesis for collect the pleural effusion at beginning of their admission,and treated for 2 or 3 weeks before the second paracentesis.The pleural effusion collected at different times was detected for CA125 level.We found that pleural effusion and serum levels of the CA125 in patients with inflammatory pleural effusion showed no significant increase compared with normal control.For the patient with tuberculous and malignant pleural effusion,the CA125 level increased significantly compared with normal（P 0.05）,furthermore,the CA125 level in effusion was slightly higher that in serum.After treatment,the CA125 level in tuberculous effusion decreased（P 0.01）,but that in malignant effusion did not changed（P 0.05）.The results indicate that Ca125 can be used in diagnosis and treatment of patients with tuberculous pleural effusion.