血糖代谢性指标与良性前列腺增生症的相关性

Study on the correlation of metabolic indicators of blood glucose and benign prostatic hyperplasia

目的探讨老年良性前列腺增生症(BPH)患者和BPH合并血糖代谢性指标异常患者的临床相关性。方法通过对老年病科门诊就诊的≥60岁BPH患者进行流行病学调查,对入选的117例BPH患者的血糖等代谢性指标空腹血糖(FBG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白(HbA1 c)与BPH评价指标:前列腺体积(PV)、血清前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)、BPH病程时间等进行统计分析和比较。结果①FBG升高的BPH患者比FBG正常的BPH患者PV增大更明显(P=0.002),PSA值亦明显升高(P=0.006),IPSS明显增加(P=0.01),而BPH病程时间两组间未发现显著性差异。②2 hPBG升高的BPH患者与2 hPBG正常的BPH患者PV、PSA值、IPSS、BPH病程时间未发现显著性差异(P>0.05)。③HbA1 c正常的BPH患者前列腺体积与HbA1 c异常的BPH患者比较显示,后者的PV明显增大(P=0.046),PSA、IPSS、BPH病程时间在两者之间未见显著性差异。结论 FBG为BPH患者病情进展的危险因素。HbA1 c在BPH病程中也起到一定的作用。FBG、HbA1 c与BPH之间存在密切关系。

Objective To investigate the influence of fasting blood glucose（FBG）,2-hour postprandial blood glucose（2 h PBG）,glycated hemoglobin（HbA1c） on the benign prostatic hyperplasia（BPH） progress.Methods 117 outpatients（≥60 years old） with BPH from geriatric department were enrolled.Metabolic indicators of blood glucose,including FBG,2 h PBG,HbA1c and indexes of BPH,including volume of prostate（PV）,prostate specific antigen（PSA）,international prostate symptom score（IPSS）,course of BPH were measured.Results Men with elevated fasting glucose were more likely to have an enlarged prostate（P=0.002）,a higher serum PSA level（P=0.006） and a much higher IPSS（P=0.01）.BPH course between the two groups had no significant difference.There was no significant difference on PV,PSA,IPSS and course of BPH between the elevated and normal 2 h PBG level groups（P0.05）.Men with elevated HbA1c level were more likely to have an enlarged prostate than those with normal HbA1c level（P=0.046）.No significant difference was discovered on PSA,IPSS and course of BPH between the two groups.Conclusions Elevated FBS level is a risk factor on BPH progression.The influence of HbA1c on BPH progression can not be ignored.The close relationship between FBS,HbA1c and BPH should be further confirmed.