治萎防变胶囊对气虚血瘀型CAG大鼠PGE_2、GAS和血浆/胃组织MOT水平的影响

Effect of Zhiweifangbian capsule on levels of prostaglandin E2,gastrin and motilin in chronic atrophic gastritis progress of rats with qi-deficiency and blood-stasis

目的探讨治萎防变胶囊对气虚血瘀型萎缩性胃炎(CAG)大鼠胃组织PGE2、血清胃泌素(GAS)和血浆/胃组织胃动素(MOT)水平的影响。方法采用综合法复制CAG动物模型。施药治疗后分别对各组大鼠血清胃组织PGE2、血清GAS和血浆/胃组织MOT含量进行检测。结果与空白组比较,模型组大鼠胃组织PGE2、血清GAS水平显著下降(P<0.01,P<0.05),血浆/胃组织MOT水平显著升高(P<0.05);与模型组比较,治萎防变胶囊可显著提高组织PGE2、血清GAS含量(P<0.05),显著降低血浆/胃组织MOT水平(P<0.05),且以治萎防变胶囊大剂量组作用显著。结论治萎防变胶囊具有调节胃酸、胃黏膜黏液分泌,调整胃动力,增加胃黏膜血流量,改善微循环,营养和修复胃黏膜的作用。

Objective To study effects of Zhiweifangbian capsule（ZWFB） on levels of prostaglandin E2,gastrin and motilin in chronic atrophic gastritis（CAG） progress of rats with qi-deficiency and blood-stasis.Methods Model of CAG was established with synthetic method.After treated with ZWFB,the gastric tissue level of prostaglandin E2,the serum level of gastrin,levels of motilin in gastric tissue and plasma were detected.Results In successful model group,the gastric tissue level of prostaglandin E2,the serum level of gastrin were much lower than those of normal group（P0.01,P0.05）,levels of motilin in gastric tissues and plasma were much higher than those of normal group（P0.05）.Compared with model group,ZWFB could increase the gastric tissue level of prostaglandin E2 and the serum level of gastrin,increase levels of motilin（P0.05） significantly.Conclusions ZWFB has functions of regulating gastric acid and gastric mucus,gastrointestinal motility and ameliorating gastric mucosal blood flow.