Application of CT perfusion imaging in detection of tumor angiogenesis in osteosarcoma

学习的目的是探索 64 片螺线的申请的目的在在人的 osteosarcoma 评估 angiogenesis 计算了断层摄影术灌注成像(CTPI ) 。方法 26 个病人(从 9 ～ 56 岁的 18 男性和 8 女性，与 19 年的一般水准) 与 osteosarcoma 经历了 64 片螺线 CTPI。我们包括血分析了 CTPI 参数的关联流动(BF ) ，血卷(BV ) ，达到顶点的时间(TTP ) ，和渗透出现(PS ) 与 angiogenesis 的标记的表达式。统计分析与对样品 t 测试被执行，并且皮尔森关联分析被采用与 microvessel 密度(MVD ) 调查 CTPI 参数的关联。osteosarcoma 组的结果平均数 BF， BV， TTP，和 PS 价值是(46.6 椠 ??

Objective： The aim of the study was to explore the application of 64-slice spiral computed tomography perfusion imaging （CTPI） in evaluating angiogenesis in human osteosarcoma. Methods： Twenty-six patients （18 males and 8 females ranging from 9 to 56 years old, with an average of 19 years） with osteosarcoma underwent 64-slice spiral CTPI. We analyzed the correlations of CTPI parameters including blood flow （BF）, blood volume （BV）, time to peak （TTP）, and permeability surface （PS） with the expression of markers of angiogenesis. Statistical analysis was performed with paired-samples t test, and Pearson correlation analysis was employed to investigate the correlations of CTPI parameters with microvessel density （MVD）. Results： Mean BF, BV, TTP, and PS values of osteosarcoma group were （46.6 ± 25.1） mL/100 g/min, （61.8 ± 29.5） mL/100 g, （122.9 ± 26.2） seconds, and （44.5 ± 14.6） mL/100 g/min, respectively. Those in the normal muscle group were （5.2 ± 6.6） mL/100 g/min, （9.6 ± 7.3） mL/100 g, （115.5 ± 33.1） seconds and （17.0 ± 29.3） mL/100 g/min, respectively. Osteosarcoma group showed higher BF, BV and PS compared with the normal muscle group （P = 0.000, P = 0.000, and P = 0.000, respectively）. However, no significant difference was found in TTP between osteosarcoma tissue and normal adjacent muscle tissue （P = 0.273）. BF, BV, and PS were positively correlated with MVD （r = 0.83, P = 0.000; r = 0.87, P = 0.000; and r = 0.63, P = 0.001, respectively）. No correlation was found between TTP and MVD （r = –0.02, P = 0.93）. Conclusion： CTPI is useful for assessing tumor vascularity of osteosarcoma and CTPI parameters are positively correlated with MVD.